Interaction between corticosterone and insulin in obesity: Regulation of lard intake and fat stores
Interaction between corticosterone and insulin in obesity: Regulation of lard intake and fat stores
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DOI：
10.1210/en.2003-1359
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发表时间：
2004-05-01
期刊：
影响因子：
4.8
通讯作者：
Dallman, MF
中科院分区：
文献类型：
--
作者：
la Fleur, SE;Akana, SF;Dallman, MF
被动升高糖皮质激素导致胰岛素增加和腹部肥胖伴外周消瘦，如在库欣综合征中观察到的，对食物摄入影响不大。在没有胰岛素的情况下（链脲佐菌素诱导的糖尿病），糖尿病大鼠的食物摄入量与糖皮质激素成比例地显著增加。给予猪油或食物的选择，糖尿病大鼠首先吃猪油，然后减少热量摄入到正常48小时，然后恢复到只吃食物的过度进食。我们进行了三个实验来确定皮质酮和胰岛素与猪油摄入量、食物摄入量、体重、激素和脂肪库的关系。这些研究的结果阐明了循环糖皮质激素和胰岛素对成年雄性大鼠热量摄入的作用。我们的实验表明，糖皮质激素引起剂量相关的总热量摄入增加，持续数天和数周;结果还表明，糖皮质激素刺激的胰岛素浓度增加决定了脂肪摄入量。此外，我们表明，猪油的摄入量与胰岛素浓度的增加。此外，肾上腺切除和肾上腺切除、链脲佐菌素诱导的糖尿病大鼠的结果强烈表明，皮质酮和胰岛素的组合增加了腹部脂肪库重量。独立的经尿道操作的大鼠，结果还表明，完整的大鼠自愿吃相当大的和稳定的比例，他们的每日热量作为猪油时，给予猪油和食物之间的选择。这些结果表明，一些人的肥胖可能是由于糖皮质激素和胰岛素的升高，增加了高密度热量的摄入比例。
Passive elevations in glucocorticoids result in increased insulin and abdominal obesity with peripheral wasting, as observed in Cushing's syndrome, with little effect on chow intake. In the absence of insulin (streptozotocin-induced diabetes) diabetic rats markedly increase their chow intake in proportion to glucocorticoids. Given a choice of lard or chow, diabetic rats first eat lard, then reduce caloric intake to normal for 48 h before returning to hyperphagia on chow alone. We performed three experiments to determine the relationship of corticosterone and insulin to lard intake, chow intake, body weight, hormones, and fat depots. The results of these studies clarify the actions of both circulating glucocorticoids and insulin on caloric intake in adult male rats. Our experiments show that glucocorticoids provoke dose-related increases in total caloric intake that persist for days and weeks; the results also suggest that increasing insulin concentrations stimulated by glucocorticoids determine the amount of fat intake. Furthermore, we show that lard intake is associated with increasing insulin concentrations. Additionally, the results in adrenalectomized and adrenalectomized, streptozotocin-induced diabetic rats strongly suggest that it is a combination of corticosterone and insulin that increases abdominal fat depot weight. Independently of the hormonally manipulated rats, the results also show that intact rats voluntarily eat a considerable and stable proportion of their daily calories as lard when given a choice between lard and chow. These results suggest that some human obesities may result from elevated glucocorticoids and insulin increasing the proportional intake of high density calories.