Non-alcoholic fatty liver disease (Nafld) in obese children- effect of refined carbohydrates in diet
Non-alcoholic fatty liver disease (Nafld) in obese children- effect of refined carbohydrates in diet
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DOI：
10.1186/s12887-016-0726-3
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发表时间：
2016-11-15
期刊：
影响因子：
2.4
通讯作者：
Coral, Gabriela Perdomo
中科院分区：
文献类型：
--
作者：
Felix, Deise Rosa;Costenaro, Fabiola;Coral, Gabriela Perdomo
背景资料：儿童肥胖症的发病率逐渐增加，与此相关，非酒精性脂肪肝（NAFLD）经常在这个年龄组中被诊断出来。为了确定与NAFLD肥胖儿童的危险因素，特别强调diet.Methods：一个前瞻性的横断面研究进行了肥胖儿童提到的内分泌门诊。有关饮食习惯和体力活动的问题被应用。此外，还收集了两次24 h食品召回。进行人体测量、生化检查和腹部超声检查。该研究获得了Irmandade Santa Casa de Misericordia de波尔图阿莱格雷医院（ISCMPA）机构审查委员会的批准。5%的统计学显著性水平被认为是statistically significant.Results：最初分配的55例患者中，39例进行了评估，8例（20.5%）诊断为NAFLD，其中男孩（87.5%）更为普遍。Logistic回归分析显示，男性是NAFLD的独立预测因素（OR：1.62; 95% CI：1.08-2.44; p = 0.038）;饮食中含有大量精制碳水化合物（OR：2.17; 95% CI：1.05 - 6.82; p = 0.038）和缺乏常规体力活动OR：3.35，95% CI：1.97 - 0.006，P = 0.006。结论：肥胖儿童NAFLD患病率较高。此外，饮食中大量精制碳水化合物、男性和久坐的生活方式是其发生的重要危险因素。
Background: The incidence of childhood obesity has increased progressively and, associated with this, nonalcoholic fatty liver disease (NAFLD) has often been diagnosed in this age group. To determine the risk factors associated with NAFLD in obese children, with special emphasis on diet.Methods: A prospective cross-sectional study was conducted with obese children referred to the endocrinology outpatient clinic. Questions about dietary habits and physical activity were applied. In addition, two 24 h food recalls were collected. Anthropometric measurements, biochemical tests and abdominal ultrasound were obtained. The study was approved by the institutional review board of Irmandade Santa Casa de Misericordia de Porto Alegre Hospital (ISCMPA). A 5% statistical significance level was considered statistically significant.Results: Of 55 patients initially allocated, 39 were evaluated and 8 (20.5%) had a diagnosis of NAFLD, which was more prevalent among boys (87.5%). Logistic regression analysis showed that the predictive factors independently associated with the presence of NAFLD were male gender (OR: 1.62; 95% CI: 1.08-2.44; p = 0.038); high amount of refined carbohydrates in the diet (OR: 2.17; 95% CI: 1.05 - 6.82; p = 0.038) and absence of routine physical activity (OR: 3.35; 95% CI: 1.97 -0.006; p = 0.006).Conclusions: The prevalence of NAFLD in obese children in our series was high. Furthermore, the high amount of refined carbohydrates in the diet, male gender and sedentary lifestyle were significant risk factors for its occurrence.