Targeting anabolic impairment in response to resistance exercise in older adults with mobility impairments: potential mechanisms and rehabilitation approaches.
Targeting anabolic impairment in response to resistance exercise in older adults with mobility impairments: potential mechanisms and rehabilitation approaches.
复制标题
针对行动障碍老年人抵抗运动的合成代谢障碍：潜在机制和康复方法。
DOI：
10.1155/2012/486930
复制
发表时间：
2012
影响因子：
4.7
通讯作者：
Lastayo,PaulC
中科院分区：
文献类型：
--
作者：
Drummond,MicahJ;Marcus,RobinL;Lastayo,PaulC
肌肉萎缩与健康衰老（即肌肉减少症）有关，并且可能因合并症、损伤、手术、疾病和缺乏身体活动而加剧。虽然一次抗阻运动可以提高健康年轻骨骼肌的蛋白质合成率，但抗阻运动对蛋白质合成反应的有效性在老年人中并不那么明显。提高抗阻运动的合成代谢敏感性，从而增强身体机能，对于临床状况导致“低反应者”的贫困老年人来说至关重要。在本文中，我们讨论了导致抗阻运动合成代谢受损的潜在机制，并强调需要改善低反应者的合成代谢反应性。随后的证据表明，抗阻运动的恢复期提供了通过摄入蛋白质/必需氨基酸来放大运动引起的合成代谢反应的机会。如果长期重复这种合成代谢策略，可以改善瘦肌肉的增长，减少康复期间功能恢复的时间，总体而言，可以维持/改善老年人的身体独立性并降低死亡率。
Muscle atrophy is associated with healthy aging (i.e., sarcopenia) and may be compounded by comorbidities, injury, surgery, illness, and physical inactivity. While a bout of resistance exercise increases protein synthesis rates in healthy young skeletal muscle, the effectiveness of resistance exercise to mount a protein synthetic response is less pronounced in older adults. Improving anabolic sensitivity to resistance exercise, thereby enhancing physical function, is most critical in needy older adults with clinical conditions that render them “low responders”. In this paper, we discuss potential mechanisms contributing to anabolic impairment to resistance exercise and highlight the need to improve anabolic responsiveness in low responders. This is followed with evidence suggesting that the recovery period of resistance exercise provides an opportunity to amplify the exercise‐induced anabolic response using protein/essential amino acid ingestion. This anabolic strategy, if repeated chronically, may improve lean muscle gains, decrease time to recovery of function during periods of rehabilitation, and overall, maintain/improve physical independence and reduce mortality rates in older adults.