Monocyte to high-density lipoprotein cholesterol ratio in patients with diabetes mellitus and diabetic nephropathy
Monocyte to high-density lipoprotein cholesterol ratio in patients with diabetes mellitus and diabetic nephropathy
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DOI：
10.2217/bmm-2018-0048
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发表时间：
2018-09-01
影响因子：
2.2
通讯作者：
Kaya, Yasemin
中科院分区：
文献类型：
--
作者：
Karatas, Ahmet;Turkmen, Ercan;Kaya, Yasemin
目的：我们研究单核细胞与高密度脂蛋白胆固醇比值（MHR）与糖尿病和糖尿病肾病的关系。方法与结果：共有 220 名糖尿病患者和 70 名健康对照者入组。正常白蛋白尿的糖尿病患者和健康对照之间的 MHR 没有差异。糖尿病肾病患者的MHR显着高于白蛋白尿正常的糖尿病患者和健康对照者。尿白蛋白肌酐比值与MHR呈显着正相关。在多元线性回归分析中，MHR 与尿白蛋白与肌酐比率独立相关。结论：MHR 升高可能是糖尿病肾病的生物标志物。
Aim: We investigated the relationship of monocyte to high-density lipoprotein cholesterol ratio (MHR) with diabetes mellitus and diabetic nephropathy. Methods & Results: A total of 220 diabetes mellitus patients and 70 healthy controls were enrolled. There was no difference in an MHR between normoalbuminuric diabetic patients and the healthy controls. The MHR in patients with diabetic nephropathy was significantly higher than that of both the normoalbuminuric diabetic patients and the healthy controls. There was a significant positive correlation between urine albumin to creatinine ratio and the MHR. In multivariate linear regression analysis, the MHR was independently correlated with urine albumin to creatinine ratio. Conclusion: An increased MHR may be a biomarker for diabetic nephropathy.