Role of glutamatergic system and mesocorticolimbic circuits in alcohol dependence.
Role of glutamatergic system and mesocorticolimbic circuits in alcohol dependence.
复制标题
DOI：
10.1016/j.pneurobio.2018.10.001
复制
发表时间：
2018-12
影响因子：
6.7
通讯作者：
Sari Y
中科院分区：
文献类型：
--
作者：
Alasmari F;Goodwani S;McCullumsmith RE;Sari Y
新出现的证据表明，酒精依赖与多种神经递质的失调有关。多巴胺、谷氨酸和γ-氨基丁酸释放的改变与长期酒精暴露有关。酒精对中皮质边缘区谷氨酸能系统的影响已得到广泛研究。几项研究表明，在暴露于酒精的动物模型中，多巴胺能系统失调。酒精暴露可导致中皮质边缘脑区细胞外谷氨酸水平增加。此外，酒精暴露会影响这些脑区中几种谷氨酸受体和谷氨酸转运体的表达和功能。本文综述了酒精暴露对中皮质边缘系统各区域谷氨酸受体、谷氨酸转运体和谷氨酸稳态的影响。此外，我们还讨论了酒精与谷氨酸和奖赏回路相关的遗传方面。我们还讨论了潜在的治疗作用，谷氨酸受体和谷氨酸转运体在每个大脑区域的治疗酒精依赖。最后，我们提供了一些限制，针对潜在的治疗酒精使用障碍的治疗选择的多巴胺能系统。
Emerging evidence demonstrates that alcohol dependence is associated with dysregulation of several neurotransmitters. Alterations in dopamine, glutamate and gamma-aminobutyric acid release are linked to chronic alcohol exposure. The effects of alcohol on the glutamatergic system in the mesocorticolimbic areas have been investigated extensively. Several studies have demonstrated dysregulation in the glutamatergic systems in animal models exposed to alcohol. Alcohol exposure can lead to an increase in extracellular glutamate levels in mesocorticolimbic brain regions. In addition, alcohol exposure affects the expression and functions of several glutamate receptors and glutamate transporters in these brain regions. In this review, we discussed the effects of alcohol exposure on glutamate receptors, glutamate transporters and glutamate homeostasis in each area of the mesocorticolimbic system. In addition, we discussed the genetic aspect of alcohol associated with glutamate and reward circuitry. We also discussed the potential therapeutic role of glutamate receptors and glutamate transporters in each brain region for the treatment of alcohol dependence. Finally, we provided some limitations on targeting the glutamatergic system for potential therapeutic options for the treatment alcohol use disorders.
登录
查看更多内容
影响因子：
4.2
作者：
Aal-Aaboda, Munaf;Alhaddad, Hasan;Osowik, Francis;Nauli, Surya M.;Sari, Youssef
通讯作者：
Sari, Youssef
影响因子：
7.6
作者：
Abulseoud, Osama A.;Camsari, Ulas M.;Choi, Doo-Sup
通讯作者：
Choi, Doo-Sup
影响因子：
5.3
作者：
Baptista, MAS;Martin-Fardon, R;Weiss, F
通讯作者：
Weiss, F
影响因子：
3.4
作者：
Bach, Patrick;Kirsch, Martina;Vollstaedt-Klein, Sabine
通讯作者：
Vollstaedt-Klein, Sabine
影响因子：
5.3
作者：
Abrahao, Karina Possa;Ariwodola, Olusegun J.;Weiner, Jeffrey L.
通讯作者：
Weiner, Jeffrey L.