COMPARISONS OF ANALGESIC EFFECTS OF ORAL AND INTRAMUSCULAR OXYMORPHONE AND OF INTRAMUSCULAR OXYMORPHONE AND MORPHINE IN PATIENTS WITH CANCER
COMPARISONS OF ANALGESIC EFFECTS OF ORAL AND INTRAMUSCULAR OXYMORPHONE AND OF INTRAMUSCULAR OXYMORPHONE AND MORPHINE IN PATIENTS WITH CANCER
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DOI：
10.1177/009127007701700402
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发表时间：
1977-01-01
影响因子：
2.9
通讯作者：
ROGERS, A
中科院分区：
文献类型：
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作者：
BEAVER, WT;WALLENSTEIN, SL;ROGERS, A
口服和静脉注射羟吗啡酮的相对镇痛效力通过分级单剂量双盲交叉比较对癌症引起的慢性疼痛患者进行评估。当考虑镇痛持续时间和强度（总效果）时，口服羟吗啡酮的效力是静脉注射形式的1/6。口服羟吗啡酮的药效峰值仅为口服羟吗啡酮的1/14。这些数值与之前比较口服吗啡和静脉注射吗啡的研究结果几乎相同。口服羟吗啡酮的镇痛作用比内服羟吗啡酮起效更晚，持续时间更长。在一个相似的患者组中，也比较了氧吗啡酮和吗啡的静脉注射效果。静脉注射羟吗啡酮的总镇痛效果是吗啡的8.7倍，峰值效果是吗啡的13倍。在大致等镇痛剂量下，口服和静脉注射羟吗啡酮以及静脉注射羟吗啡酮和吗啡的副作用发生在定性和定量上相似。
The relative analgesic potency of oral and i.m. oxymorphone was evaluated in a double-blind crossover comparison of graded single doses in patients with chronic pain due to cancer. When both duration and intensity of analgesia were considered (total effect), oral oxymorphone was 1/6 as potent as the i.m. form. In terms of peak effect oral oxymorphone was only 1/14 as potent. These values were almost identical to those obtained in a previous study comparing oral with i.m. morphine. The analgesic effect of oral oxymorphone rose to a peak later and had a longer duration than the effect of i.m. oxymorphone. I.m. oxymorphone and morphine were also compared in a similar patient group. I.m. oxymorphone was 8.7 times as potent as morphine in terms of total analgesic effect and 13 times as potent in terms of peak effect. In roughly equianalgesic doses, the occurrence of side effects was qualitatively and quantitatively similar for oral and i.m. oxymorphone and for i.m. oxymorphone and morphine.