Serum WFA+-M2BP is a non-invasive liver fibrosis marker that can predict the efficacy of direct-acting anti-viral-based triple therapy for chronic hepatitis C
Serum WFA+-M2BP is a non-invasive liver fibrosis marker that can predict the efficacy of direct-acting anti-viral-based triple therapy for chronic hepatitis C
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DOI：
10.1111/apt.13431
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发表时间：
2016-01-01
影响因子：
7.6
通讯作者：
Hayashi, J.
中科院分区：
文献类型：
--
作者：
Ura, K.;Furusyo, N.;Hayashi, J.
研究背景花紫藤凝集素阳性人Mac-2结合蛋白（WFA（+）-M2 BP）是一种新的肝纤维化糖标志物，具有独特的肝纤维化相关糖改变。目的探讨WFA（+）-M2 BP在肝纤维化诊断中的临床应用价值及预测直接抗病毒药物（DAA）疗效的临床应用价值。该研究包括159名接受基于DAA治疗的基因型1型丙型肝炎患者，（特拉匹韦或西米匹韦）联合聚乙二醇干扰素α加利巴韦林（108例特拉匹韦和51例西米匹韦三联治疗）。结果血清WFA（+）-M2 BP水平随肝纤维化程度的加重而明显升高。接受者工作特征曲线下面积分析确定2.17为WFA（+）-M2 BP诊断晚期纤维化的临界指数（COI）。持续病毒学应答（SVR）率与血清WFA（+）-M2 BP水平呈显著负相关。多因素Logistic回归分析发现血清WFA（+）-M2 BP水平较低（
BackgroundThe Wisteria floribunda agglutinin-positive human Mac-2-binding protein (WFA(+)-M2BP) is a new liver fibrosis glycobiomarker with unique fibrosis-related glyco-alteration. WFA(+)-M2BP is also a useful surrogate marker for the risk of developing hepatocellular carcinoma and for the liver functional reserve.AimTo evaluate the diagnostic ability of WFA(+)-M2BP for liver fibrosis in the clinical setting and the clinical utility of WFA(+)-M2BP for predicting the efficacy of direct-acting anti-viral (DAA) treatment for chronic hepatitis C patients.MethodsThe study included 159 genotype 1 hepatitis C patients who received DAA-based treatment (telaprevir or simeprevir) combined with pegylated-interferon alpha plus ribavirin (108 telaprevir-and 51 simeprevir-based triple treatment). The relation between baseline serum WFA(+)-M2BP and treatment efficacy was evaluated.ResultsThe serum WFA(+)-M2BP level significantly increased with the progress of liver fibrosis. Area under the receiver operating characteristic curve analysis identified 2.17 as the cut-off index (COI) for WFA(+)-M2BP for diagnosing advanced fibrosis. The sustained virological response (SVR) rate was significantly, negatively correlated with the serum WFA(+)-M2BP level. Multiple logistic regression analysis found a low serum WFA(+)-M2BP level (