Distinct mechanisms of apoptosis-induced compensatory proliferation in proliferating and differentiating tissues in the Drosophila eye
Distinct mechanisms of apoptosis-induced compensatory proliferation in proliferating and differentiating tissues in the Drosophila eye
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DOI：
10.1016/j.devcel.2008.01.003
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发表时间：
2008-03-01
影响因子：
11.8
通讯作者：
Bergmann, Andreas
中科院分区：
文献类型：
--
作者：
Fan, Yun;Bergmann, Andreas
在多细胞生物体中，凋亡细胞诱导邻近细胞的代偿性增殖以维持组织稳态。在果蝇翅盘中，垂死细胞通过分泌有丝分裂原Decapentaplegic（Dpp）和Wingless（Wg）触发代偿性增殖。这一过程是在启动caspase Dronc的控制下，但不是效应caspase。在这里，我们表明，第二种机制的乳腺癌诱导的代偿性增殖存在。该机制依赖于效应物半胱天冬酶，其触发Hedgehog（Hh）信号传导的激活以进行补偿性增殖。此外，尽管Dpp和Wg信号传导优先用于凋亡增殖组织，但Hh信号传导在分化的眼组织中被激活。有趣的是，光感受器神经元中的效应器半胱天冬酶刺激Hh信号传导，其触发先前退出细胞周期的细胞的细胞周期再进入。总之，依赖于受影响组织的发育潜力，不同的半胱天冬酶在明显的非凋亡功能中触发不同形式的代偿性增殖。
In multicellular organisms, apoptotic cells induce compensatory proliferation of neighboring cells to maintain tissue homeostasis. In the Drosophila wing imaginal disc, dying cells trigger compensatory proliferation through secretion of the mitogens Decapentaplegic (Dpp) and Wingless (Wg). This process is under control of the initiator caspase Dronc, but not effector caspases. Here we show that a second mechanism of apoptosis-induced compensatory proliferation exists. This mechanism is dependent on effector caspases which trigger the activation of Hedgehog (Hh) signaling for compensatory proliferation. Furthermore, whereas Dpp and Wg signaling is preferentially employed in apoptotic proliferating tissues, Hh signaling is activated in differentiating eye tissues. Interestingly, effector caspases in photoreceptor neurons stimulate Hh signaling which triggers cell-cycle reentry of cells that had previously exited the cell cycle. In summary, dependent on the developmental potential of the affected tissue, different caspases trigger distinct forms of compensatory proliferation in an apparent nonapoptotic function.