INTERLEUKIN-1 IN HUMAN SKIN - DYSREGULATION IN PSORIASIS
INTERLEUKIN-1 IN HUMAN SKIN - DYSREGULATION IN PSORIASIS
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DOI：
10.1111/1523-1747.ep12505698
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发表时间：
1990-11-01
影响因子：
6.5
通讯作者：
FISHER, G
中科院分区：
文献类型：
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作者：
COOPER, KD;HAMMERBERG, C;FISHER, G
细胞因子失调是一个有吸引力的概念来解释银屑病中观察到的许多异常。尤其是IL-1，可以增强免疫细胞的激活，激活成纤维细胞，增加内皮细胞与白细胞的粘附性。在这里，我们回顾了IL-1在正常皮肤和银屑病患者体内的调节，以及与正常皮肤和培养的角质形成细胞的关系。与预期相反，与正常皮肤相比，银屑病皮损中IL-1的功能活性减少，而不是增加。这种减少是由于IL-1抑制剂的存在，IL-1α水平的降低，以及在T细胞检测中缺乏功能的IL-1β。白介素1β蛋白在银屑病皮损中明显升高，但其非功能性机制尚不清楚。与培养的角质形成细胞积累大量不活跃的IL-1β前体不同，正常皮肤和银屑病患者的皮肤都会将IL-1β转化为成熟的形式。体内表皮翻译后处理的新机制可能会产生一种功能未知的新型IL-1β。银屑病患者皮肤中IL-1调节的显著异常提示，该分子可能在正常皮肤的动态平衡中起重要作用。
Cytokine dysregulation is an attractive concept to explain many of the observed abnormalities in psoriasis. IL-1, in particular, can potentiate immune cellular activation, activate fibroblasts, and increase endothelial cell adhesiveness to leukocytes. Here, we review IL-1 regulation in normal and psoriatic skin in vivo in relation to normal skin and cultured keratinocytes. Contrary to expectations, IL-1 functional activity in psoriatic lesions is reduced, not increased, relative to normal skin. The reduction is attributable to the presence of IL-1 inhibitors, reduced IL-1α levels, and an IL-1β that lacked function in T-cell assays. IL-1β protein is actually significantly increased in psoriatic lesions, but the mechanism of its non-functionality remains unclear. Unlike cultured keratinocytes, which accumulate large, inactive IL-1β precursors, both normal and psoriatic skin process IL-1β to a mature form. Novel mechanisms of post-translational processing by epidermis in vivo may generate a novel form of IL-1β with unknown functions. The marked abnormalities of IL-1 regulation in psoriatic skin suggest that this molecule may be important in normal skin homeostasis.