In vivo mapping of amyloid toxicity in Alzheimer disease
In vivo mapping of amyloid toxicity in Alzheimer disease
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DOI：
10.1212/wnl.0b013e3181a2e896
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发表时间：
2009-04-28
期刊：
影响因子：
9.9
通讯作者：
Rinne, J. O.
中科院分区：
文献类型：
--
作者：
Frisoni, G. B.;Lorenzi, M.;Rinne, J. O.
目的：探讨阿尔茨海默病(AD)患者脑灰质萎缩与淀粉样蛋白沉积的关系。方法：对23例AD患者和17例健康老年人进行体积磁共振(MR)和[C-11]-PIB PET检查。标准化的[C-11]-PIB摄取值与标准空间中的MR扫描共同配准。通过基于体素(p<；0.05校正)和感兴趣区(ROI)的分析，评估AD患者与对照组相比灰质中[C-11]-PIB摄取的密度降低和增加。用基于体素的Pearson r图(以p<；0.05为阈值)和ROI线性回归图研究灰质[C-11]-PIB摄取减少和增加之间的关系。结果：萎缩位于海马区，[C-11]-PIB摄取增加到额叶、顶叶和后扣带回皮质。ROI分析显示，海马(2.01)和杏仁核(1.27)萎缩的效应大小最大，额叶(2.66)、扣带/脾后(2.43)、岛叶(2.41)和颞区(2.23)摄取[C-11]-PIB的效应大小最大。在海马区，[C-11]-PIB摄取显著增加，但影响较小(1.72)。萎缩与[C-11]-PIB摄取增加在海马(r=-0.54)和杏仁核(r=-0.40)中显著相关，而在额叶、颞叶、扣带/脾后后部、岛叶和尾状核(r在0.04~0.25之间)无显著相关性。结论：内侧颞叶可能对淀粉样蛋白毒性高度敏感，而新皮质可能更具弹性。神经病学(R)2009；72：1504-1511
Objective: To study the relationship between gray matter atrophy and amyloid deposition in Alzheimer disease (AD).Methods: Volumetric magnetic resonance (MR) and [C-11]-PIB PET were acquired from 23 patients with AD and 17 healthy older persons. Standardized [C-11]-PIB uptake values were coregistered to MR scans in a standard space. Decreased density of and increased [C-11]-PIB uptake in the gray matter of patients with AD vs controls were assessed with both voxel-based (p < 0.05 corrected) and region-of-interest (ROI) analyses. The relationship between decreased density of and increased [C-11]-PIB uptake in the gray matter was investigated with voxel-based Pearson r maps (thresholded at p < 0.05) and ROI linear regression plots.Results: Atrophy mapped to the hippocampus and increased [C-11]-PIB uptake to large frontal, parietal, and posterior cingulate cortical areas. ROI analysis showed the largest effect size for atrophy in the hippocampus (2.01) and amygdala (1.27) and the highest effect size for [C-11]-PIB uptake in frontal (2.66), posterior cingulate/retrosplenial (2.43), insular (2.41), and temporal (2.23) regions. In the hippocampus, [C-11]-PIB uptake was significantly increased, but effect size was milder (1.72). Significant correlations between atrophy and increased [C-11]-PIB uptake were found in the hippocampal (r = -0.54) and amygdalar ROIs (r = -0.40) but not in the frontal, temporal, posterior cingulate/retrosplenial, insular, and caudate ROIs (r between 0.04 and 0.25).Conclusion: The medial temporal lobe might be highly susceptible to amyloid toxicity, whereas neocortical areas might be more resilient. Neurology (R) 2009; 72: 1504-1511