Lewis acid-catalyzed enantioselective hydroxylation reactions of oxindoles and β-keto esters using DBFOX ligand
Lewis acid-catalyzed enantioselective hydroxylation reactions of oxindoles and β-keto esters using DBFOX ligand
复制标题
DOI：
10.1021/ja0668825
复制
发表时间：
2006-12-27
影响因子：
15
通讯作者：
Kanemasa, Shuji
中科院分区：
文献类型：
--
作者：
Ishimaru, Takehisa;Shibata, Norio;Kanemasa, Shuji
描述了使用DBFOX−Zn（II）络合物的3-芳基和3-烷基-2-羟吲哚的第一个催化对映选择性羟基化反应，导致药学上重要的手性3-羟基-2-羟吲哚。氧化剂的结构对提高对映选择性起着重要作用。该方法已成功应用于使用DBFOX−Ni（II）配合物进行β-酮酯的高度对映选择性羟基化。
The first catalytic enantioselective hydroxylation reaction of both 3-aryl and 3-alkyl-2-oxindoles using the DBFOX−Zn(II) complex, leading to pharmaceutically important chiral 3-hydroxy-2-oxindoles was described. The structure of oxidant was found to play an important role to increase the enantioselectivity. The methodology has successfully applied to the highly enantioselective hydroxylation of β-keto esters using the DBFOX−Ni(II) complex.