Clinical Differences in Japanese Patients Between Brugada Syndrome and Arrhythmogenic Right Ventricular Cardiomyopathy With Long-Term Follow-Up
Clinical Differences in Japanese Patients Between Brugada Syndrome and Arrhythmogenic Right Ventricular Cardiomyopathy With Long-Term Follow-Up
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DOI：
10.1016/j.amjcard.2019.05.067
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发表时间：
2019-09-01
影响因子：
2.8
通讯作者：
Kusano, Kengo
中科院分区：
文献类型：
--
作者：
Kataoka, Naoya;Nagase, Satoshi;Kusano, Kengo
一些Brugada综合征（BrS）患者被怀疑处于致瘤性右心室心肌病（ARVC）的初始状态。本研究旨在阐明BrS和ARVC在长期随访（平均11.9 +/- 6.3年）中的心电图（ECG）和临床差异。共50例BrS和65例ARVC患者的致命性室性快速性心律失常（VTA）进行了评估，根据修订的工作组标准的ARVC。根据目前关于心电图的诊断标准，基线和随访时复极异常分别在2.0%和2.6%的BrS患者中为阳性，基线和随访时去极化异常分别在6.0%和12.8%的BrS患者中为阳性。在基线时，没有BrS患者被明确诊断为ARVC。考虑到患者自出生以来的生活，Kaplan-Meier分析显示，两组首次VTA发作时的年龄显示出相同的趋势（BrS：平均42.2 ± 12.5岁vs ARVC：平均44.8 ± 13.7岁，对数秩p = 0.123）。此外，随访期间两组VTA复发率相似（对数秩p = 0.906）。ARVC中持续性单形性室性心动过速的发生率显著高于BrS，而心室颤动的发生率则相反（对数秩检验p
Some Brugada syndrome (BrS) patients have been suspected of being in the initial state of arrhythmogenic right ventricular cardiomyopathy (ARVC). This study aimed to clarify the electrocardiographic (ECG) and clinical differences between BrS and ARVC in longterm follow-up (mean 11.9 +/- 6.3 years). A total of 50 BrS and 65 ARVC patients with fatal ventricular tachyarrhythmia (VTA) were evaluated according to the revised Task Force Criteria for ARVC. Based on the current diagnostic criteria concerning electrocardiographic, repolarization abnormality was positive in 2.0% and 2.6% of BrS patients at baseline and follow-up, and depolarization abnormality was positive in 6.0% and 12.8% of BrS patients at baseline and follow-up, respectively. At baseline, none of the BrS patients were definitively diagnosed with ARVC. Considering patients' lives since birth, Kaplan-Meier analysis revealed that age at first VTA attack showed the same tendency between the groups (BrS: mean 42.2 +/- 12.5 years old vs ARVC: mean 44.8 +/- 13.7 years old, log-rank p = 0.123). Moreover, the incidence of VTA recurrence was similar between the groups during follow-up (log-rank p = 0.906). Incidence of sustained monomorphic ventricular tachycardia was significantly higher in ARVC than in BrS whereas the opposite was true for ventricular fibrillation (log-rank p