EFFECT OF THE IMPLANTABLE LEFT-VENTRICULAR ASSIST DEVICE ON NEUROENDOCRINE ACTIVATION IN HEART-FAILURE
EFFECT OF THE IMPLANTABLE LEFT-VENTRICULAR ASSIST DEVICE ON NEUROENDOCRINE ACTIVATION IN HEART-FAILURE
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DOI：
10.1161/01.cir.92.9.191
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发表时间：
1995-11-01
期刊：
影响因子：
37.8
通讯作者：
BRAVO, E
中科院分区：
文献类型：
--
作者：
JAMES, KB;MCCARTHY, PM;BRAVO, E
Background The HeartMate left ventricular assist device has been successfully used as a bridge to cardiac transplantation. Because many patients exhibit marked clinical improve ment in their heart failure after HeartMate implantation, we studied the physiological effect of this device on the neurohormonal axis.Methods and Results In 13 patients; awaiting transplant (mean cardiac index, 1.7+/-0.3 L . min(-1). m(-2)) who underwent HeartMate implantation, venous atrial natriuretic peptide, epinephrine, norepinephrine, plasma renin activity, angiotensin, and arginine vasopressin were measured immediately before insertion and at explant/transplantation. Mean time to explant was 86+/-40 days. All patients were taken off inotropic medications within 1 month. Mean cardiac index on support before explant was 3.1+/-0.9 L . min(-1). m(-2). Plasma renin activity decreased from 57+/-56 ng . mL(-1). h(-1) at baseline (before insertion) to 3+/-3 ng . mL(-1). h(-1) at explant (mean percent change, 92%; P
