Neuropsychiatric symptoms in patients with multiple sclerosis
Neuropsychiatric symptoms in patients with multiple sclerosis
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DOI：
10.1111/j.1600-0447.2005.00624.x
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发表时间：
2005-12-01
影响因子：
6.7
通讯作者：
Aarsland, D
中科院分区：
文献类型：
--
作者：
Figved, N;Klevan, G;Aarsland, D
目的：探讨多发性硬化症（MS）患者的精神症状范围及其与神经功能障碍的关系。方法：纳入了1998-2000年挪威西部罗加兰县和霍达兰县诊断为多发性硬化症的患者。精神症状通过神经精神病量表（NPI）进行评估。系统性红斑狼疮 (SLE) 患者作为对照。结果：93 名符合条件的 MS 患者中有 86 名被纳入，其中 80% 表现出至少一种精神症状。最常见的症状是抑郁（59%）、睡眠障碍（48%）、烦躁/情绪不稳定（42%）和冷漠（31%）。抑郁症与较高的残疾评分相关。 MS患者的NPI烦躁评分（P = 0.002）、食欲障碍评分（P < 0.001）和冷漠评分（P = 0.01）显着高于SLE患者。结论：MS患者经常出现神经精神症状。烦躁和冷漠与残疾和慢性疾病无关，代表独特的疾病表现。
Objective: To explore the range of psychiatric symptoms in patients with multiple sclerosis (MS) and their association with neurological disability.Method: Patients diagnosed with MS during 1998-2000 in Rogaland and Hordaland counties, western Norway, were included. Psychiatric symptoms were assessed by the Neuropsychiatric Inventory (NPI). Patients with systemic lupus erythematosus (SLE) served as controls.Results: Eighty-six of 93 eligible MS patients were included, and 80% showed at least one psychiatric symptom. The most frequent symptoms were depression (59%), sleep disturbance (48%), irritability/emotional lability (42%), and apathy (31%). Depression was associated with higher disability score. MS patients showed significantly higher NPI irritability score (P = 0.002), appetite disturbance score (P < 0.001), and apathy score (P = 0.01) than SLE patients.Conclusion: Neuropsychiatric symptoms occur frequently in patients with MS. Irritability and apathy are independent of disability and chronic disease and represent unique disease manifestations.