DOSE-RATE EFFECT OF RADIATION ON RAT MAMMARY CARCINOGENESIS AND AN EMERGING ROLE FOR STEM CELL BIOLOGY
DOSE-RATE EFFECT OF RADIATION ON RAT MAMMARY CARCINOGENESIS AND AN EMERGING ROLE FOR STEM CELL BIOLOGY
复制标题
辐射对大鼠乳腺癌发生的剂量率效应以及干细胞生物学的新兴作用
DOI：
10.1093/rpd/ncac050
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发表时间：
2022
影响因子：
1
通讯作者：
Kakinuma Shizuko
中科院分区：
文献类型：
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作者：
Imaoka Tatsuhiko;Nishimura Mayumi;Daino Kazuhiro;Hosoki Ayaka;Kudo Ken-ichi;Iizuka Daisuke;Nagata Kento;Takabatake Masaru;Nishimura Yukiko;Kokubo Toshiaki;Morioka Takamitsu;Doi Kazutaka;Shimada Yoshiya;Kakinuma Shizuko
在低剂量率下长时间辐射暴露的不确定的癌症风险是放射防护中的一个重要问题。组织干细胞/祖细胞被认为是癌症的起源，并可能在癌症发生的剂量率效应中起作用。作者已经证明，与急性照射相比，在青少年或青年时期接受持续全身γ照射的雌性大鼠患乳腺癌的几率显著降低。使用乳房形成试验的实验表明，存在抗辐射的祖细胞。细胞分类显示，大鼠乳腺基底祖细胞比腔祖细胞对急性辐射的杀伤能力更强，尤其是在高剂量辐射下。因此，证据表明，乳腺细胞的失活依赖于细胞类型，只有在高急性剂量时才表现出来，这意味着与观察到的致癌剂量率效应有关。
The uncertain cancer risk of protracted radiation exposure at low dose rates is an important issue in radiological protection. Tissue stem/progenitor cells are a supposed origin of cancer and may contribute to the dose-rate effect on carcinogenesis. The authors have shown that female rats subjected to continuous whole bodyγirradiation as juveniles or young adults have a notably reduced incidence of mammary cancer as compared with those irradiated acutely. Experiments using the mammosphere formation assay suggested the presence of radioresistant progenitor cells. Cell sorting indicated that basal progenitor cells in rat mammary gland were more resistant than luminal progenitors to killing by acute radiation, especially at high doses. Thus, the evidence indicates a cell-type-dependent inactivation of mammary cells that manifests only at high acute doses, implying a link to the observed dose-rate effect on carcinogenesis.