BNP-Guided vs Symptom-Guided Heart Failure Therapy The Trial of Intensified vs Standard Medical Therapy in Elderly Patients With Congestive Heart Failure (TIME-CHF) Randomized Trial
BNP-Guided vs Symptom-Guided Heart Failure Therapy The Trial of Intensified vs Standard Medical Therapy in Elderly Patients With Congestive Heart Failure (TIME-CHF) Randomized Trial
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DOI：
10.1001/jama.2009.2
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发表时间：
2009-01-28
影响因子：
120.7
通讯作者：
Brunner-La Rocca, Hans-Peter
中科院分区：
文献类型：
--
作者：
Pfisterer, Matthias;Buser, Peter;Brunner-La Rocca, Hans-Peter
背景目前尚不确定N-末端脑钠肽（BNP）指导的心力衰竭强化治疗是否上级症状指导治疗。目的比较N-末端BNP指导与BNP指导的心力衰竭治疗的18个月结局。设计，设置，老年充血性心力衰竭患者强化与标准药物治疗的随机对照多中心临床研究499例年龄≥ 60岁的收缩性心力衰竭（射血分数）患者的TIMECHF
Context It is uncertain whether intensified heart failure therapy guided by N- terminal brain natriuretic peptide ( BNP) is superior to symptom- guided therapy.Objective To compare 18- month outcomes of N- terminal BNP - guided vs symptomguided heart failure therapy.Design, Setting, and Patients Randomized controlled multicenter Trial of Intensified vs Standard Medical Therapy in Elderly Patients With Congestive Heart Failure ( TIMECHF) of 499 patients aged 60 years or older with systolic heart failure ( ejection fraction