Cessation of HIV-1 Transcription by Inhibiting Regulatory Protein Rev-Mediated RNA Transport
Cessation of HIV-1 Transcription by Inhibiting Regulatory Protein Rev-Mediated RNA Transport
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DOI：
10.2174/157016209787048564
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发表时间：
2009-01-01
影响因子：
1
通讯作者：
De Clercq, Erik
中科院分区：
文献类型：
--
作者：
Cao, Yuan;Liu, Xinyong;De Clercq, Erik
HIV-1 Rev蛋白通过核仁运输并在细胞核和细胞质之间穿梭，通过CRM 1输出途径促进含有RRE RNA的未剪接和单剪接病毒转录物的输出。抑制Rev介导的RNA转运的各个阶段可以阻止HIV-1的转录过程。综述了Rev的作用机制、Rev与RRE的相互作用及其抑制剂的研究进展。
The HIV-1 Rev protein, which traffics through nucleolus and shuttles between nucleus and cytoplasm, facilitates export of unspliced and singly spliced viral transcripts containing RRE RNA by the CRM1 export pathway. Inhibitions of the various stages of Rev-mediated RNA transport can arrest HIV-1 transcriptional process. The current understanding to the mechanism of Rev function, Rev-RRE interaction, as well as inhibitors hereof is reviewed.