CHANGES DURING DEVELOPMENT IN TRANSPORT PROCESSES OF BLOOD-BRAIN-BARRIER
CHANGES DURING DEVELOPMENT IN TRANSPORT PROCESSES OF BLOOD-BRAIN-BARRIER
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DOI：
10.1016/0005-2736(76)90120-6
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发表时间：
1976-01-01
期刊：
影响因子：
--
通讯作者：
OLDENDORF, WH
中科院分区：
文献类型：
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作者：
CREMER, JE;BRAUN, LD;OLDENDORF, WH
在15天至9周龄的大鼠中研究了血脑屏障对几类化合物的渗透性。将14 C标记的供试品与2种参比同位素3 H2O和113 mIn标记的EDTA同时注入颈总动脉，10 s后断头。有证据表明，15-23日龄大鼠的单羧酸转运系统的能力至少是成年动物的6倍。L-乳酸盐和乙酸盐的渗透性最高。在所有年龄段，L-乳酸和（-）D-3-羟丁酸值之间的比例是恒定的。D-葡萄糖的渗透性随着年龄的增长而增加，而几种氨基酸的测试是相同的年轻和成年大鼠。
The permeability of the blood-brain barrier to several classes of compounds was studied in rats 15 days to 9 wk old. 14C-labeled test substances were injected simultaneously with 2 reference isotopes, 3H2O and 113mIn-labeled EDTA, into the common carotid artery, followed by decapitation 10 s later. There was evidence that a monocarboxylic acid transport system in 15-23 day old rats had a capacity at least 6 times greater than that present in adult animals. L-Lactate and acetate showed the highest permeability. At all ages there was a constant ratio between L-lactate and (-)D-3-hyroxybutyrate values. D-Glucose permeability increased with age, while that of several amino acids tested was the same in young and adult rats.