Recent enhancements to the Blocks Database servers
Recent enhancements to the Blocks Database servers
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DOI：
10.1093/nar/25.1.222
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发表时间：
1997-01-01
影响因子：
14.9
通讯作者：
Henikoff, S
中科院分区：
文献类型：
--
作者：
Henikoff, JG;Pietrokovski, S;Henikoff, S
Blocks数据库包含蛋白质家族中保守区域的多个比对，可以通过电子邮件（blocks@blocks.fhcrc.org）和万维网（http：//blocks.fhcrc.org/）搜索来分类蛋白质和核苷酸序列。最近对sewers的改进包括：（i）改进了从区块计算位置特异性评分矩阵的方法;（ii）可利用Prints蛋白质指纹数据库以区块格式进行搜索;（iii）偏向于蛋白质家族区块的代表性序列;（iv）从蛋白质家族区块构建的树;（v）与家族相关万维网网页的链接;以及（vi）新的多个对准的局部对准（LAMA）方法，以针对块的数据库搜索块。
The Blocks Database contains multiple alignments of conserved regions in protein families which can be searched by e-mail (blocks@blocks.fhcrc.org) and World Wide Web (http://blocks.fhcrc.org/) sewers to classify protein and nucleotide sequences. Recent enhancements to the sewers include: (i) improved calculation of position-specific scoring matrices from blocks; (ii) availability of the Prints protein fingerprint database for searching in Blocks format; (iii) a representative sequence biased towards the Blocks of a protein family; (iv) a tree constructed from the Blocks of a protein family; (v) links to related World Wide Web pages for a family; and (vi) the new Local Alignment of Multiple Alignments (LAMA) method to search a block against a database of blocks.