Completing the puzzle: The search for pieces in the understanding of psychosis risk in 22q11.2 deletion syndrome.
Completing the puzzle: The search for pieces in the understanding of psychosis risk in 22q11.2 deletion syndrome.
复制标题
完成拼图：寻找理解 22q11.2 缺失综合征精神病风险的片段。
DOI：
10.1016/j.schres.2017.07.040
复制
发表时间：
2017
影响因子：
4.5
通讯作者：
Shashi,Vandana
中科院分区：
文献类型：
--
作者：
Hooper,StephenR;Shashi,Vandana
In this issue of Schizophrenia Research, Kates and colleagues provide an exemplary study examining the longitudinal trajectories of cortical thickness as a potential biomarker for later developing psychosis for younger individuals with 22q11. 2 Deletion Syndrome (22q11DS). Although parallel efforts in first episode schizophrenia have produced such connections, Kates et al. provide some of the first data showing a linkage between brain architecture and later psychotic presentation in this well-known genetic condition using a longitudinal design. Specifically, these investigators found significant relationships between targeted cortical regions of the frontal lobe, particularly differential neurodevelopmental trajectories of cortical thickness, and later emergent prodromal positive psychotic symptoms. Issues pertinent to the synaptic pruning process are implicated as underlying mechanisms for these neuroanatomical anomalies. These findings are complemented by another article in this issue by Mekori-Domachevsky et al. whose work suggests the importance of monitoring negative symptoms for psychotic manifestations in the 22q11DS population.Both studies were well executed with associated operational measurement and attention to details such as diagnostic reliability and validity for both the neuroimaging and behavioral domains. The studies employed state-of-the-art measurement to address the assessment challenges inherent in testing this population. In that regard, these studies represent superb scientific efforts to address core issues related to the psychopathology and underlying brain systems inherent to 22q11DS. Further, it is important to note that these investigations, one a multi-site study and the other a longitudinal investigation over a span of about 10 years, are not easy exercises, but their collective findings represent additional diagnostic and mechanistic pieces to the puzzle of our understanding of individuals with 22q11DS.
