Dynamic Biomaterials: Cyclic Stiffness Modulation of Cell‐Laden Protein–Polymer Hydrogels in Response to User‐Specified Stimuli Including Light (Adv. Biosys. 12/2018)
Dynamic Biomaterials: Cyclic Stiffness Modulation of Cell‐Laden Protein–Polymer Hydrogels in Response to User‐Specified Stimuli Including Light (Adv. Biosys. 12/2018)
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动态生物材料：细胞负载蛋白质聚合物水凝胶响应用户指定刺激（包括光）的循环刚度调节（Adv. Biosys. 12/2018）
DOI：
10.1002/adbi.201870111
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发表时间：
2018
影响因子：
4.1
通讯作者：
DeForest, Cole A.
中科院分区：
文献类型：
--
作者：
Liu, Luman;Shadish, Jared A.;Arakawa, Christopher K.;Shi, Kevin;Davis, Jennifer;DeForest, Cole A.
在第1800240号文章中，科尔A. DeForest及其同事证明，与刺激响应性融合蛋白交联的水凝胶生物材料在暴露于用户指定的环境线索时可以经历完全可逆的硬化。基于光遗传蛋白LOV 2和Jα构建的凝胶在蓝光下几乎瞬间软化，从而能够在活细胞存在下时空控制水凝胶的顺应性。
In article number 1800240, Cole A. DeForest and co-workers demonstrate that hydrogel biomaterials crosslinked with stimuli-responsive fusion proteins can undergo fully reversible stiffening upon exposure to user-specified environmental cues. Gels built upon optogenetic proteins LOV 2 and Jα soften near-instantaneously under blue light, enabling spatiotemporal control of hydrogel compliance in the presence of living cells.