Regulation of cell death by the ubiquitin-proteasome system.

Regulation of cell death by the ubiquitin-proteasome system.
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DOI:
10.1016/j.ceb.2009.09.005
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发表时间:
2009-12
影响因子:
7.5
通讯作者:
Steller H
Steller H
中科院分区:
生物学2区
文献类型:
--
作者:
Bader M;Steller H

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细胞凋亡(程序性细胞死亡)的调控已经成为大量研究的主题,因为它涉及正常发育、组织稳态和广泛的疾病。泛素-蛋白酶体系统(UPS)通过靶向细胞死亡的关键蛋白,包括凋亡的中央执行者半胱天冬酶,在细胞凋亡的控制中起着突出的作用。在这里,我们总结了UPS在促凋亡和抗凋亡调节中的功能的主要发现。
The regulation of apoptosis (programmed cell death) has been the subject of a vast body of research because of its implication in normal development, tissue homeostasis and a wide range of diseases. The ubiquitin-proteasome system (UPS) plays a prominent role in the control of apoptosis by targeting key cell death proteins, including caspases, the central executioners of apoptosis. Here we summarize the major findings on the function of the UPS in both pro- and anti- apoptotic regulation.
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