The role of IL-18 in the modulation of matrix metalloproteinases and migration of human natural killer (NK) cells
The role of IL-18 in the modulation of matrix metalloproteinases and migration of human natural killer (NK) cells
复制标题
DOI：
10.1016/j.febslet.2004.05.039
复制
发表时间：
2004-07-02
期刊：
影响因子：
3.5
通讯作者：
Ishii, N
中科院分区：
文献类型：
--
作者：
Ishida, Y;Migita, K;Ishii, N
在这项研究中，我们研究了白细胞介素-18（IL-18）是否影响自然杀伤（NK）细胞的迁移和基质金属蛋白酶（MMPs）的产生。我们证明了IL-18增强了人NK细胞通过基底膜样基质胶的趋化性。同样，IL-18刺激诱导活化形式的基质金属蛋白酶-2（MMP-2）的产生以及来自NK细胞的pro-MMP-2的产生。我们还证明了人NK细胞上的MT 1-MMP表达，其是MMP-2的主要活化剂，通过与MMP-2活化协调的IL-18刺激诱导。这些数据表明，MT 1-MMP/MMP-2系统参与了基底膜成分的降解，从而有助于NK细胞的迁移。(C)2004年欧洲生物化学学会联合会。Elsevier B. V.出版，保留所有权利。
In this study, we examined whether interleukin-18 (IL-18) affects natural killer (NK) cells' migration and matrix metalloproteinases (MMPs) production. We demonstrated that chemotaxis of human NK cells through basement membrane-like Matrigel was augmented by IL-18. As well, IL-18 stimulation induces the production of activated forms of matrix metalloproteinase-2 (MMP-2) as well as the production of pro-MMP-2 from NK cells. We also demonstrated that MT1-MMP expression on human NK cells, which is a major activator of MMP-2, was induced by IL-18 stimulation coordinated with MMP-2 activation. These data suggest that the MT1-MMP/MMP-2 system participates in the degradation of basement membrane components and thus contributes to NK cell migration. (C) 2004 Federation of European Biochemical Societies. Published by Elsevier B.V. All rights reserved.