Serum vitamin C and the prevalence of vitamin C deficiency in the United States: 2003-2004 National Health and Nutrition Examination Survey (NHANES)
Serum vitamin C and the prevalence of vitamin C deficiency in the United States: 2003-2004 National Health and Nutrition Examination Survey (NHANES)
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DOI：
10.3945/ajcn.2008.27016
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发表时间：
2009-11-01
影响因子：
7.1
通讯作者：
Lacher, David A.
中科院分区：
文献类型：
--
作者：
Schleicher, Rosemary L.;Carroll, Margaret D.;Lacher, David A.
背景：维生素C（抗坏血酸）可能是人体血浆中最重要的水溶性抗氧化剂。在第三次全国健康和营养检查调查（NHANES III，1988-1994）中，大约13%的美国人口缺乏维生素C（2003-2004年全国代表性NHANES横截面期间的血清浓度为6 y）。缺乏症的患病率进行了比较，结果从NHANES III。结果：从平方根转换（SM）浓度的总体年龄调整后的平均值为51.4 μ mol/L（95%CI：48.4，54.6）。儿童和老年人体内的浓度最高。在每个种族-民族组中，女性的浓度高于男性（P < 0.05）。成年吸烟者的平均浓度比非吸烟者低三分之一（SM：男性35.2 μ mol/L，女性50.7 μ mol/L，男性38.6 μ mol/L，女性58.0 μ mol/L）。年龄调整的维生素C缺乏的总体患病率（+/- SE）为7.1 +/-0.9%。随着社会经济地位的提高，平均维生素C浓度升高（P < 0.05），维生素C缺乏症患病率降低（P < 0.01）。结论：2003-2004年NHANES中维生素C状况有所改善，维生素C缺乏的患病率明显低于NHANES III，但吸烟者和低收入者维生素C缺乏的风险增加。美国临床营养杂志2009; 90：1252-63。
Background: Vitamin C (ascorbic acid) may be the most important water-soluble antioxidant in human plasma. In the third National Health and Nutrition Examination Survey (NHANES III, 1988-1994), approximate to 13% of the US population was vitamin C deficient (serum concentrations 6 y during the cross-sectional, nationally representative NHANES 2003-2004. The prevalence of deficiency was compared with results from NHANES III.Results: The overall age-adjusted mean from the square-root transformed (SM) concentration was 51.4 mu mol/L (95% CI: 48.4, 54.6). The highest concentrations were found in children and older persons. Within each race-ethnic group, women had higher concentrations than did men (P < 0.05). Mean concentrations of adult smokers were one-third lower than those of nonsmokers (SM: 35.2 compared with 50.7 mu mol/L and 38.6 compared with 58.0 mu mol/L in men and women, respectively). The overall prevalence (+/- SE) of age-adjusted vitamin C deficiency was 7.1 +/- 0.9%. Mean vitamin C concentrations increased (P < 0.05) and the prevalence of vitamin C deficiency decreased (P < 0.01) with increasing socioeconomic status. Recent vitamin C supplement use or adequate dietary intake decreased the risk of vitamin C deficiency (P < 0.05).Conclusions: In NHANES 2003-2004, vitamin C status improved, and the prevalence of vitamin C deficiency was significantly lower than that during NHANES III, but smokers and low-income persons were among those at increased risk of deficiency. Am J Clin Nutr 2009; 90: 1252-63.