The neural correlates underlying the regulation of anticipation on regret
The neural correlates underlying the regulation of anticipation on regret
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后悔预期调节背后的神经相关性
DOI：
10.1016/j.bbr.2022.114075
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发表时间：
2022-08-28
影响因子：
2.7
通讯作者：
Liu，Zhiyuan
中科院分区：
文献类型：
--
作者：
Liu，Sijia;Li，Shuang;Liu，Zhiyuan
遗憾是日常生活中常见的负面情绪，长期沉浸在遗憾之中会影响心理健康。因此，规范和减少遗憾受到广泛关注。目前的功能磁共振成像研究旨在调查决策前的结果预期是否可以减少后悔及其神经相关性。在任务中，参与者被要求预测后续决策可能出现的不良结果，例如错过奖励和受到惩罚，然后做出连续的冒险决策。行为结果表明，决策前对结果的预期可以降低后悔的强度，即，与在没有事先预期结果的情况下做出连续的冒险决策（非预期条件，NAt）相比，当参与者在决策前预期结果（预期条件，Ant）时，他们感到更少的后悔。一致地，在神经水平上，与 Nant 相比，观察到腹侧纹状体 (VS) 和背侧内侧前额叶皮质 (dmPFC) 的活动更强，并且 VS-dmPFC 功能连接性更强。此外，dmPFC的活性与Ant的后悔强度呈负相关。本研究强调，决策前的结果预期可以有效调节遗憾，而 dmPFC 在这一过程中发挥了至关重要的作用。
Regret is a common negative emotion in daily life, and long-term immersion in regret affects mental health. Therefore, to regulate and reduce regret is of wide concern. The current fMRI study aimed to investigate whether outcome anticipation before decision-making could reduce regret and its neural correlates. In the task, participants were asked to anticipate the possible poor outcomes of subsequent decisions, such as missing rewards and meeting punishment, and then made sequential risk-taking decisions. Behavioral results showed that outcome anticipation before decision-making could decrease the intensity of regret, that is, participants felt less regret when they anticipated the outcome before decision-making (anticipation condition,Ant), compared to making sequential risk-taking decisions without any anticipation of the outcome in advance (non-anticipation condition,NAnt). Consistently, at the neural level, stronger activities of ventral striatum (VS) and dorsal medial prefrontal cortex (dmPFC), and greater VS-dmPFC functional connectivity were observed inAntrelative toNAnt. Moreover, the activity of dmPFC was negatively correlated with the intensity of regret inAnt. The current study highlighted that outcome anticipation before decision-making could regulate regret effectively, and dmPFC played a vital role in this process.