2-D Ultrasonic Array-Based Optical Coherence Elastography.
2-D Ultrasonic Array-Based Optical Coherence Elastography.
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DOI：
10.1109/tuffc.2020.3033304
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发表时间：
2021-04
期刊：
影响因子：
--
通讯作者：
Zhou Q
中科院分区：
文献类型：
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作者：
Kang H;Qian X;Chen R;Wodnicki R;Sun Y;Li R;Li Y;Shung KK;Chen Z;Zhou Q
声辐射力光学相干弹性成像（ARF-OCE）已成功地实现了表征的生物力学特性的软组织，如角膜和视网膜的高分辨率使用单元件超声换能器的ARF激励。目前提出的大多数OCE技术，如喷气和ARF，有能力控制的时空信息的诱导区域的变形，导致有限的精度和低的时间分辨率的剪切波弹性成像。在这项研究中，我们提出了一种新的方法称为二维超声阵列的光学相干弹性成像，它结合了三维动态电子转向的二维超声阵列和高分辨率光学相干断层扫描（OCT）的优点。2D阵列的3D转向能力首先使用水听器进行验证。然后，组合的二维超声阵列OCE系统使用一个同质体模进行校准，然后在离体兔角膜组织上进行实验。结果表明，我们新开发的基于二维超声阵列的OCE系统具有准确映射组织生物力学特性的能力，因此有可能成为眼科重要的诊断工具。
Acoustic radiation force optical coherence elastography (ARF-OCE) has been successfully implemented to characterize the biomechanical properties of soft tissues such as the cornea and the retina with high resolution using single-element ultrasonic transducers for ARF excitation. Most currently proposed OCE techniques, such as air-puff and ARF, have less capability to control the spatiotemporal information of the induced region of deformation, resulting in limited accuracy and low temporal resolution of the shear wave elasticity imaging. In this study, we propose a new method called 2D ultrasonic array-based optical coherence elastography imaging, which combines the advantages of 3D dynamic electronic steering of the 2D ultrasonic array and high-resolution optical coherence tomography (OCT). The 3D steering capability of the 2D array was first validated using a hydrophone. Then, the combined 2D ultrasonic array OCE system was calibrated using a homogenous phantom, followed by an experiment on ex vivo rabbit corneal tissue. The results demonstrate that our newly developed 2D ultrasonic array-based OCE system has the capability to map tissue biomechanical properties accurately, and therefore has the potential to be a vital diagnostic tool in ophthalmology.