Dynamics of endothelial cell behavior in sprouting angiogenesis
Dynamics of endothelial cell behavior in sprouting angiogenesis
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DOI：
10.1016/j.ceb.2010.08.010
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发表时间：
2010-10-01
影响因子：
7.5
通讯作者：
Adams, Ralf H.
中科院分区：
文献类型：
--
作者：
Eilken, Hanna M.;Adams, Ralf H.
脊椎动物体内含有广泛的血管网络，除了少数例外，该网络是由现有脉管系统中的内皮芽形成的。这个过程被称为血管生成，涉及内皮细胞与其环境之间复杂且高度动态的相互作用。促血管生成信号，例如 VEGF，促进内皮运动、丝状伪足延伸和增殖，并与 Notch 信号一起控制特定内皮细胞是否成为前导尖端细胞或尾随茎细胞。然后芽转化为内皮小管并与其他血管形成连接，这需要局部抑制运动并形成新的细胞-细胞连接。我们在此回顾了控制尖端细胞选择、萌芽和新血管形成的关键分子和途径背景下的血管生成动力学。
The vertebrate body contains an extensive blood vessel network that forms, with a few exceptions, by endothelial sprouting from the existing vasculature. This process, termed angiogenesis, involves complex and highly dynamic interactions between endothelial cells and their environment. Pro-angiogenic signals, such as VEGF, promote endothelial motility, filopodia extension and proliferation, and, together with Notch signaling, controls whether specific endothelial cells become lead tip cells or trailing stalk cells. Sprouts then convert into endothelial tubules and form connections with other vessels, which requires the local suppression of motility and the formation of new cell-cell junctions. We here review the dynamics of angiogenesis in the context of key molecules and pathways controlling tip cell selection, sprouting and the formation of new vessels.