Antidepressant-like effect by postsynaptic 5-HT1A receptor activation in mice.
Antidepressant-like effect by postsynaptic 5-HT1A receptor activation in mice.
复制标题
通过激活小鼠突触后 5-HT1A 受体而产生抗抑郁样作用。
DOI：
10.1016/0014-2999(95)00254-i
复制
发表时间：
1995
影响因子：
5
通讯作者：
A. Baba
中科院分区：
文献类型：
--
作者：
T. Matsuda;P. Somboonthum;M. Suzuki;S. Asano;A. Baba
研究了新型5-羟色胺受体激动剂5-{3-[(2S)-1,4-苯并二氮杂-2-甲基)氨基]丙氧基}-1,3-苯并二氮杂唑（MKC-242）在小鼠强制游泳实验中的抗抑郁样作用，并分别给小鼠注射5,7-二羟色胺破坏5-羟色胺或对氯苯丙氨酸抑制5-羟色胺的合成。MKC-242减少了用载药和这些药物预处理的小鼠的静止时间，但不影响它们的运动活动。5- ht1a受体拮抗剂如普萘洛尔和n-叔丁基-3-（4-（2-甲氧基苯基）哌嗪-1-基）-2-苯基丙酰胺可拮抗其不动作用。这些发现支持了突触后5- ht1a受体在5- ht1a受体激动剂的抗抑郁样作用中起重要作用的假设。
The antidepressant-like effect of 5-{3-[((2S)-1,4-benzodioxan-2-ylmethyl)amino]propoxy}-1,3-benzodioxole (MKC-242), a novel 5-HT1Areceptor agonist, was studied in the forced swimming test in mice injected i.c.v. with 5,7-dihydroxytryptamine to destroy 5-HT neurons or treated with p-chlorophenylalanine to inhibit 5-HT synthesis. MKC-242 reduced immobility time of mice pretreated with vehicle and these drugs, although it did not affect their locomotor activity. The anti-immobility effect was antagonized by 5-HT1Areceptor antagonists such as propranolol and N-tert-butyl-3-(4-(2-methoxyphenyl)piperazin-1-yl)-2-phenylpropanamide. These findings support the hypothesis that postsynaptic 5-HT1Areceptors play an important role in the antidepressant-like effect of 5-HT1Areceptor agonists.