Structural Aspects of Auxin Signaling
Structural Aspects of Auxin Signaling
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DOI：
10.1101/cshperspect.a039883
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发表时间：
2022-01-01
影响因子：
7.2
通讯作者：
Strader, Lucia C.
中科院分区：
文献类型：
--
作者：
Morffy, Nicholas;Strader, Lucia C.
生长素信号调节植物的生长和发育过程。核生长素信号的核心依赖于三个组件：TIR 1/AFB，Aux/IAAs和ARF。每个组分本身由几个结构域组成，所有这些结构域都有助于调节生长素信号传导。对这三个核心信号组分结构方面的研究加深了我们对生长素信号动力学和调控的理解。除了这些组分的结构域之外，蛋白质内的固有无序区域也影响生长素信号传导结果。新的研究开始揭示内在障碍在生长素调节的降解和亚细胞定位中的作用。结构和内在无序结构域影响生长素的感知，蛋白质降解动力学和DNA结合。总的来说，每类生长素信号组分的结构域和基序的细微差异影响信号结果和特异性。
Auxin signaling regulates growth and developmental processes in plants. The core of nuclear auxin signaling relies on just three components: TIR1/AFBs, Aux/IAAs, and ARFs. Each component is itself made up of several domains, all of which contribute to the regulation of auxin signaling. Studies of the structural aspects of these three core signaling components have deepened our understanding of auxin signaling dynamics and regulation. In addition to the structured domains of these components, intrinsically disordered regions within the proteins also impact auxin signaling outcomes. New research is beginning to uncover the role intrinsic disorder plays in auxin-regulated degradation and subcellular localization. Structured and intrinsically disordered domains affect auxin perception, protein degradation dynamics, and DNA binding. Taken together, subtle differences within the domains and motifs of each class of auxin signaling component affect signaling outcomes and specificity.