Gene expression profiling reveals molecular marker candidates of laryngeal squamous cell carcinoma
Gene expression profiling reveals molecular marker candidates of laryngeal squamous cell carcinoma
复制标题
DOI：
10.3892/or_00000268
复制
发表时间：
2009-03-01
期刊：
影响因子：
4.2
通讯作者：
Rahal, Paula
中科院分区：
文献类型：
--
作者：
Colombo, Jucimara;Fachel, Angela A.;Rahal, Paula
喉鳞状细胞癌在头颈癌中十分常见，死亡率高，预后差。在这项研究中，我们使用定制的 cDNA 微阵列比较了来自 13 个喉肿瘤和 10 个非肿瘤性喉组织的临床样本的表达谱，该微阵列包含 331 个探针，针对 284 个基因，这些基因先前通过 EST 数据库的信息学分析确定为头颈肿瘤的标记。 35 个基因显示出统计显着差异（SNR >= 11.01，p
Laryngeal squamous cell carcinoma is very common in head and neck cancer, with high mortality rates and poor prognosis. In this study, we compared expression profiles of clinical samples from 13 larynx tumors and 10 non-neoplastic larynx tissues using a custom-built cDNA microarray containing 331 probes for 284 genes previously identified by informatics analysis of EST databases as markers of head and neck tumors. Thirty-five genes showed statistically significant differences (SNR >= 11.01, p