Matched-pair analysis of a multi-institutional cohort reveals that epidermal growth factor receptor mutation is not a risk factor for postoperative recurrence of lung adenocarcinoma
Matched-pair analysis of a multi-institutional cohort reveals that epidermal growth factor receptor mutation is not a risk factor for postoperative recurrence of lung adenocarcinoma
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DOI：
10.1016/j.lungcan.2017.09.003
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发表时间：
2017-12-01
期刊：
影响因子：
5.3
通讯作者：
Okada, Yoshinori
中科院分区：
文献类型：
--
作者：
Matsumura, Yuki;Suzuki, Hiroyuki;Okada, Yoshinori
目的：目前尚不清楚表皮生长因子受体（EGFR）突变状态是否是手术切除的肺腺癌（ADC）术后复发的危险因素。因此，我们进行了一项多机构研究，采用配对分析，根据EGFR突变状态比较肺ADC患者的无复发生存期（RFS）和总生存期（OS）。研究方法：我们收集了2005年至2012年期间在五个参与机构接受肺ADC手术切除的909例患者的记录，并检查了他们的EGFR突变状态。对于每例EGFR突变的患者，我们选择一个野生型EGFR序列，并根据机构，年龄，性别，吸烟史，病理分期（pStage）和辅助治疗进行匹配。我们比较RFS和OS的匹配cohol.Results：患者被分配到组（n = 181）突变或野生型EGFR序列。两个队列具有相同的特征，如下所示：机构、中位年龄（68岁）、男性（85，47%）、曾经吸烟者（77，43%）和pStage（IA，108，60%; IB，48，27%; II，14，8%; III，11，6%）。突变型或野生型EGFR序列患者的3年和5年RFS率分别为79%、68%和77%、68%（p = 0.557）。两组的总生存率分别为92%、81%和89%、79%（p = 0.574）。结论：配对多中心分析显示EGFR突变不是肺腺癌术后复发的显著危险因素。
Objective: It is unclear whether epidermal growth factor receptor (EGFR) mutation status is a risk factor for postoperative recurrence of surgically resected lung adenocarcinoma (ADC). Therefore, we conducted a multi-institutional study employing matched-pair analysis to compare recurrence-free survival (RFS) and overall survival (OS) of patients with lung ADC according to EGFR mutation status. Methods: We collected the records of 909 patients who underwent surgical resection for lung ADC between 2005 and 2012 at five participating institutions and were also examined their EGFR mutation status. For each patient with an EGFR mutation, we selected one with the wild-type EGFR sequence and matched them according to institution, age, gender, smoking history, pathological stage (pStage), and adjuvant treatment. We compared RFS and OS of the matched cohort.Results: The patients were allocated into groups (n = 181 each) with mutated or wild-type EGFR sequences. Both cohorts had identical characteristics as follows: institution, median age (68 years), men (85, 47%), ever smokers (77, 43%), and pStage (IA, 108, 60%; IB, 48, 27%; II, 14, 8%; III, 11, 6%). The 3-and 5-year RFS rates of patients with mutated or wild-type EGFR sequence were 79%, 68% and 77%, 68%, respectively (p = 0.557). The respective OS rates were 92%, 81%, and 89%, 79% (p = 0.574).Conclusion: Matched-pair and multi-institutional analysis reveals that an EGFR mutation was not a significant risk factor for recurrence of patients with surgically resected lung adenocarcinoma.