HYPOXIC-REPERFUSION INJURY IN THE INFLAMED HUMAN JOINT
HYPOXIC-REPERFUSION INJURY IN THE INFLAMED HUMAN JOINT
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DOI：
10.1016/s0140-6736(89)91305-6
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发表时间：
1989-02-11
期刊：
影响因子：
168.9
通讯作者：
LUNEC, J
中科院分区：
文献类型：
--
作者：
BLAKE, DR;MERRY, P;LUNEC, J
一系列实验表明，在发炎的人膝关节运动中，关节内压力高于滑膜毛细血管灌注压，导致关节内缺氧；停止运动后，关节内的脂质和免疫球蛋白受到氧化损伤。这些发现与滑膜炎症持续存在的假说是一致的，即滑膜炎症的持续存在可能是由于运动性缺氧-再灌注损伤所致。
A series of experiments showed that, on exercise of the inflamed human knee, intra-articular pressure rises above synovial capillary perfusion pressure, causing intra-articular hypoxia; and that, on cessation of exercise, there is oxidative damage to lipids and IgG within the joint. These findings are consistent with the hypothesis that persistence of synovial inflammation can be due to exercise-induced hypoxic-reperfusion injury mediated by reactive oxygen species.