Airway glucose concentrations and effect on growth of respiratory pathogens in cystic fibrosis
Airway glucose concentrations and effect on growth of respiratory pathogens in cystic fibrosis
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DOI：
10.1016/j.jcf.2006.03.009
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发表时间：
2007-04-01
影响因子：
5.2
通讯作者：
Baker, Emma H.
中科院分区：
文献类型：
--
作者：
Brennan, Amanda L.;Gyi, Khin M.;Baker, Emma H.
背景：囊性纤维化相关糖尿病（CFRD）的肺功能衰退加速，与葡萄糖耐受不良的严重程度成正比，但机制尚不清楚。在没有 CF 的人群中，当血糖 (BG) >= 8 mmol L-1（气道阈值）时，气道葡萄糖 (AG) 浓度升高，并且与呼吸道感染相关。方法：为了确定 BG 和 AG 之间的关系，40 名 CF 患者接受了配对 BG 和 AG（鼻腔）测量。通过连续 BG 监测，比较 10 名 CFRD、10 名糖耐量正常 (CF-NGT) 的 CF 患者和 10 名健康志愿者每日 BG>气道阈值的时间。气道葡萄糖浓度对细菌生长的影响在体外通过光学密度测定法测定。结果：AG 出现的频率更高（85%-vs.-19%，p= 8 mmol L-1 预测 CF 中 AG 浓度升高，至少在鼻分泌物中）。CFRD 患者有 50% 的天 BG > 气道阈值，这意味着 AG 浓度持续升高。需要进一步研究以确定气道葡萄糖浓度升高是否会导致 CFRD 肺部加速衰退。 (C) 2006 年欧洲囊性纤维化协会由 Elsevier B.V 出版。保留所有权利。
Background: Pulmonary decline accelerates in cystic fibrosis-related diabetes (CFRD) proportional to severity of glucose intolerance, but mechanisms are unclear. In people without CF, airway glucose (AG) concentrations are elevated when blood glucose (BG) >= 8 mmol L-1 (airway threshold), and are associated with acquisition of respiratory infection.Methods: To determine the relationship between BG and AG, 40 CF patients underwent paired BG and AG (nasal) measurements. Daily time with BG>airway threshold was compared in 10 CFRD, 10 CF patients with normal glucose tolerance (CF-NGT) and 10 healthy volunteers by continuous BG monitoring. The effect of glucose at airway concentrations on bacterial growth was determined in vitro by optical densitometry.Results: AG was present more frequently (85%-vs.-19%, p= 8 mmol L-1 predicted elevated AG concentrations in CF, at least in nasal secretions. CFRD patients spent similar to 50% day with BG>airway threshold, implying persistently elevated AG concentrations. Further studies are required to determine whether elevated airway glucose concentrations contribute to accelerated pulmonary decline in CFRD. (C) 2006 European Cystic Fibrosis Society. Published by Elsevier B.V. All rights reserved.