Alcohol consumption and prostate cancer risk: Results from the Melbourne collaborative cohort study
Alcohol consumption and prostate cancer risk: Results from the Melbourne collaborative cohort study
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DOI：
10.1002/ijc.21983
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发表时间：
2006-09-15
影响因子：
6.4
通讯作者：
Giles, Graham G.
中科院分区：
文献类型：
--
作者：
Baglietto, Laura;Severi, Gianluca;Giles, Graham G.
尽管几乎没有证据支持饮酒与前列腺癌风险之间的关联，但关于饮酒对侵袭性和非侵袭性肿瘤的影响以及饮酒的模式和类型仍然存在问题。在一项前瞻性队列研究中，招募了16,872名年龄在27-70岁之间的男性，并从1994年至2003年底进行了随访，通过当地人群癌症登记确定了732例前列腺癌，包括132例侵袭性病例和53例前列腺癌死亡。酒精消费的详细信息由经过培训的访谈者使用结构化问卷在基线时获取。总体而言，酒精摄入与前列腺癌发病率无关。与戒酒者相比，每天饮酒1-19克的男性患侵袭性前列腺癌的几率略有降低（风险比0.67; 95%置信区间（CI）0.43，1.06）和前列腺癌死亡率（风险比0.56; 95% CI 0.28，1.14），但非侵袭性前列腺癌的风险接近于1（风险比1.09; 95% CI 0.85，1.40）。我们的研究结果表明，饮酒并不影响前列腺癌的总体发病率，但我们发现提示性证据表明，饮酒可能会降低侵袭性前列腺癌的发病率和死亡率。(c)2006年威利-利斯。Inc.
Although there is little evidence to support an association between alcohol consumption and prostate cancer risk, questions remain concerning the effect on aggressive and nonaggressive tumours and the pattern and type of alcohol consumed. In a prospective cohort of 16,872 men aged 27-70 years at recruitment and followed-up from 1994 to the end of 2003, 732 incident prostate cancers were identified through the local population cancer registry, including 132 aggressive cases and 53 prostate cancer deaths. Detailed information on alcohol consumption was taken at baseline by trained interviewers using a structured questionnaire. Overall, alcohol intake was not associated with prostate cancer incidence. Compared to abstainers, men consuming 1-19 g/d of alcohol had a slightly reduced incidence of aggressive prostate cancers (hazard ratio 0.67; 95% confidence interval (CI) 0.43, 1.06) and prostate cancer mortality (hazard ratio 0.56; 95% CI 0.28, 1.14), but their risk of nonaggressive prostate cancers was close to unity (hazard ratio 1.09; 95% CI 0.85, 1.40). No significant association with pattern of drinking or type of alcoholic beverage was found. Our results show that alcohol consumption does not influence overall prostate cancer incidence but we found suggestive evidence that alcohol consumption might decrease the incidence of aggressive prostate cancer and mortality. (c) 2006 Wiley-Liss. Inc.