Intrahepatic Fat Content and Markers of Hepatic Fibrosis in Obese Children.
Intrahepatic Fat Content and Markers of Hepatic Fibrosis in Obese Children.
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肥胖儿童的肝内脂肪含量和肝纤维化标志物。
DOI：
10.1155/2016/4890974
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发表时间：
2016
影响因子：
2.8
通讯作者：
Fu J
中科院分区：
文献类型：
--
作者：
Wu W;Zhang H;Xu X;Huang K;Fu J
瞄准我们评估了肥胖儿童的直接和间接肝纤维化标志物及其与肝内脂肪（IHF）含量的关系。我们还旨在研究IHF和纤维化标志物在代谢综合征（MS）中的可能作用。方法.根据IHF和血清丙氨酸转氨酶（ALT）水平将189例肥胖儿童分为单纯性肥胖（NASH）组、单纯性脂肪变性（SS）组和非酒精性脂肪性肝炎（NASH）组。还对MS组分进行评分。通过质子磁共振波谱（1H-MRS）将IHF评估为连续变量。此外，30名非肥胖儿童作为对照组，他们的直接肝纤维化标志物和IHF进行了评估。结果年龄与IHF、NFS和FIB-4相关。NFS和APRI与IHF的相关性均较直接标志物显著。在肝功能损害的估计中，间接标志物的AUROC大于直接标志物。在MS中，IHF和所有纤维化标志物显示相似的AUROC。结论.直接和间接标志物在评价MS中均具有重要作用，间接标志物在鉴别脂肪性肝炎中更有效。即使在儿童中，年龄也是导致肝脂肪变性和纤维化的重要因素。
Aim. We evaluated both direct and indirect hepatic fibrosis markers in obese children and their relationship with intrahepatic fat (IHF) content. We also aimed to investigate the possible roles of IHF and fibrosis markers in metabolic syndrome (MS). Methods. 189 obese children were divided into simple obese (SOB), simple steatosis (SS), and nonalcoholic steatohepatitis (NASH) groups according to their IHF and blood alanine transaminase (ALT) levels. They were also scored for the MS components. IHF was assessed as a continuous variable by proton magnetic resonance spectroscopy (1H-MRS). In addition, 30 nonobese children were enrolled as controls and their direct hepatic fibrosis markers and IHF were assessed. Results. Age was related to IHF, NFS, and FIB-4. Both NFS and APRI were related to IHF more significantly than the direct markers. In the estimation of liver function impairment, indirect markers had greater AUROC than direct markers. In MS, IHF and all the fibrosis markers showed similar AUROC. Conclusions. Both direct and indirect markers played a valuable role in evaluating MS. Indirect markers were more effective in distinguishing fatty hepatitis. Age is an important factor underlying hepatic steatosis and fibrosis even in children.