Meiotic CENP-C is a shepherd: bridging the space between the centromere and the kinetochore in time and space.
Meiotic CENP-C is a shepherd: bridging the space between the centromere and the kinetochore in time and space.
复制标题
减数分裂的CENP-C是一个牧羊人：在时空和空间上桥接了丝粒和动粒之间的空间。
DOI：
10.1042/ebc20190080
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发表时间：
2020-09-04
影响因子：
6.4
通讯作者：
中科院分区：
文献类型：
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作者：
虽然许多参与着丝粒和着丝粒的蛋白质在减数分裂中是保守的，但由于在减数分裂过程中同源分离的独特需要，它们经常获得新的功能。CENP-C是有丝分裂中着丝粒组装的着丝粒的关键成分。然而，最近的工作强调了减数分裂CENP-C的独特特征。着丝粒的建立和稳定需要在着丝粒上加载CENP-C以实现CENP-A的功能。同源重组和内聚所必需的减数分裂前蛋白质装载也依赖于CENP-C，着丝点的主要支架成分也是如此。这项工作的大部分依赖于新技术，这些新技术使减数分裂的体内分析成为可能，这是前所未有的。在这里，我们努力强调这种高度保守的着丝粒蛋白的独特作用，它在m期开始之前装载到着丝粒上，但通过染色体分离继续执行关键功能。CENP-C不仅是连接着丝粒和着丝粒的结构纽带，也是连接前期早期同源突触到中期后期着丝粒组装和信号传导过程的功能纽带。
While many of the proteins involved in the mitotic centromere and kinetochore are conserved in meiosis, they often gain a novel function due to the unique needs of homolog segregation during meiosis I. CENP-C is a critical component of the centromere for kinetochore assembly in mitosis. Recent work, however, has highlighted the unique features of meiotic CENP-C. Centromere establishment and stability require CENP-C loading at the centromere for CENP-A function. Pre-meiotic loading of proteins necessary for homolog recombination as well as cohesion also rely on CENP-C, as do the main scaffolding components of the kinetochore. Much of this work relies on new technologies that enable in vivo analysis of meiosis like never before. Here we strive to highlight the unique role of this highly conserved centromere protein that loads onto centromeres prior to M-phase onset, but continues to perform critical functions through chromosome segregation. CENP-C is not merely a structural link between the centromere and the kinetochore, but also a functional one joining the processes of early prophase homolog synapsis to late metaphase kinetochore assembly and signaling.