Applying narrow-band imaging in complement with white-light imaging cystoscopy in the detection of urothelial carcinoma of the bladder
Applying narrow-band imaging in complement with white-light imaging cystoscopy in the detection of urothelial carcinoma of the bladder
复制标题
应用窄带成像与白光成像膀胱镜检查互补来检测膀胱尿路上皮癌。
DOI：
10.1016/j.urolonc.2011.02.009
复制
发表时间：
2013-05-01
影响因子：
2.7
通讯作者：
Zhang, Xu
中科院分区：
文献类型：
--
作者：
Chen, Guangfu;Wang, Baojun;Zhang, Xu
目的：目的探讨窄谱成像（NBI）膀胱软镜在膀胱尿路上皮癌（UC）诊断中的价值。材料与方法：收集2009年1月至2010年8月解放军总医院收治的179例临床疑诊UC、有肉眼血尿的患者的临床资料。这些患者接受了白光成像（WLI）膀胱镜检查，然后进行NBI。对肿瘤进行可视化、成像和记录。对可疑的UC进行活检或经尿道电切治疗，然后送病理检查。结果：143例患者经WLI和NBI检查证实为UC，共检出肿瘤285个。NBI和WLI的患者水平检出率分别为97.9%（140/143）和88.8%（127/143）（P = 0.002）。NBI和WLI的患者水平假阳性检出率分别为21.8%（39/179）和29.1%（52/179）（P = 0.12）。NBI在143例患者中的44例（30.8%）中共检测到59例额外肿瘤（17.2%; 34 pTa，17 pT 1，3 pT 2和5 pTis）。NBI发现34例中有1个额外肿瘤，6例中有2个额外肿瘤，3例中有3个额外肿瘤，1例中有4个额外肿瘤。每例患者确定的UC的平均+/- SD（范围）数量为NBI的1.97 +/- 0.67（1-5）和WLI的1.78 +/- 0.53（1-4）（P = 0.01）。NBI和WLI的肿瘤检出率分别为96.8%和79.3%（P < 0.001）。它具有较高的检出率和相对较高的假阳性检出率。NBI简单，不需要染色。它可以方便地应用于WLI的补充。(C)2013 Elsevier Inc. All rights reserved.
Objectives: To investigate the value of narrow-band imaging (NBI) flexible cystoscopy in the detection of urothelial carcinoma (UC) of the bladder.Materials and methods: Clinical data of 179 patients with suspected UC, who presented with gross hematuria, were collected at China PLA General Hospital from January 2009 to August 2010. These patients underwent white-light imaging (WLI) cystoscopy followed by NBI. The tumors were visualized, imaged, and recorded. Suspected UCs were biopsied or treated by transurethral resection, and then sent for pathologic examination. Detection results for NBI and WLI were compared.Results: WLI and NBI confirmed UC in 143 patients; a total of 285 tumors were detected. The patient-level detection rates for NBI and WLI were 97.9% (140/143) and 88.8% (127/143), respectively (P = 0.002). The patient-level false-positive detection rates for NBI and WLI were 21.8% (39/179) and 29.1% (52/179), respectively (P = 0.12). NBI detected a total of 59 additional tumors (17.2%; 34pTa, 17pT1, 3pT2, and 5pTis) in 44 of 143 patients (30.8%). NBI found 1 additional tumor in 34 cases, 2 additional tumors in 6 cases, 3 additional tumors in 3 cases, and 4 additional tumors in 1 case. The mean +/- SD (range) number of identified UCs per patient was 1.97 +/- 0.67 (1-5) for NBI and 1.78 +/- 0.53 (1-4) for WLI (P = 0.01). The tumor-level detection rates for NBI and WLI were 96.8% and 79.3%, respectively (P < 0.001).Conclusions: Compared with WLI, NBI improves UC detection. It has a higher rate of detection and a comparative rate of false-positive detection. NBI is simple and requires no dyeing. It can be conveniently applied to complement WLI. (C) 2013 Elsevier Inc. All rights reserved.