Thermodynamic phase transition parameters of human lens dihydrosphingomyelin.
Thermodynamic phase transition parameters of human lens dihydrosphingomyelin.
复制标题
人晶状体二氢鞘磷脂的热力学相变参数。
DOI：
10.1159/000267977
复制
发表时间：
1996
影响因子：
2.1
通讯作者：
Yappert,MC
中科院分区：
文献类型：
--
作者：
Borchman,D;Byrdwell,WC;Yappert,MC
Dihydrosphingomyelin (DHS) is the major phospholipid in the human lens. The influence of this phospholipid on mem brane structure and function is not known. In this study we used infrared spectroscopy to determine the thermodynamic and molecular structural properties of the hydrocarbon chains of DHS membranes isolated from human lenses. The phase transition temperature of human lens DHS was 9 C higher than for bovine brain sphingomyelin membranes and 14 and 7 C higher than human lens cortical and nuclear membranes, respectively. This increase in the phase transition temperature results in a 20% increase in lipid order at 36 C in comparison to that of native membranes and bovine brain sphingomyelin. DHS is likely to provide structural order to the hydrocarbon chain region and upholds the integrity of native membranes under oxidative conditions.
