Immunocytochemical demonstration of PHI and its co-existence with VIP in intestinal nerves of the rat and pig.
Immunocytochemical demonstration of PHI and its co-existence with VIP in intestinal nerves of the rat and pig.
复制标题
大鼠和猪肠神经中 PHI 及其与 VIP 共存的免疫细胞化学演示。
DOI：
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发表时间：
1983
期刊：
影响因子：
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通讯作者：
Tsuneo Fujita
中科院分区：
文献类型：
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作者：
Noboru Yanaihara;Kiyoshi Nokihara;C. Yanaihara;Toshihiko Iwanaga;Tsuneo Fujita
大鼠和猪的免疫细胞化学研究表明，对PHI（最近由TATEMOTO和MUTT，1981年从猪肠中分离出的七肽）的免疫反应性位于回肠和结肠中的许多神经纤维中。肌间神经丛和粘膜下神经丛含有丰富的PHI免疫反应纤维。用抗-PHI和抗-VIP血清交替染色相邻切片表明，PHI免疫反应性神经与VIP神经一致。这两种肽在相同神经元中的共存可能是由于它们可能共享共同的前体。
Immunocytochemical studies of the rat and pig indicate that immunoreactivity for PHI (heptacosapeptide recently isolated by TATEMOTO and MUTT, 1981, from the porcine intestine) is located in numerous nerve fibers in the ileum and colon. Myenteric and submucosal plexuses contain abundant PHI-immunoreactive fibers. Alternate staining of adjacent sections with anti-PHI and anti-VIP sera indicates that PHI-immunoreactive nerves coincide with VIP nerves. This co-existence of both peptides in the same neurons may be accounted for by their probable sharing of a common precursor.