A surgical experience with five hundred thirty liver transplants in the rat.
A surgical experience with five hundred thirty liver transplants in the rat.
复制标题
作者：
N. Kamada;Calne Ry
回顾了 530 例大鼠原位肝移植的手术经验和技术细节。大鼠肝移植可以提供包括免疫学在内的多个领域的重要数据。然而，技术问题限制了这一有价值的调查工具的广泛使用。微血管吻合术的袖带技术简化了门静脉吻合术，并最大限度地减少了受者的无肝期。这些曾经是大鼠肝移植失败的最常见原因。在最近的 85 例移植中，发现此处描述的大鼠肝移植技术是可靠的，长期存活率（超过 100 天）为 95.3%，其中排斥不是一个因素。根据早期经验，大多数死亡是由于出血、感染和胆道并发症。技术的进步已经消除了大部分错误。我们认为，使用这些技术修改将增加其他人手中的大鼠肝移植的成功率。
A surgical experience with 530 orthotopic liver transplants in rats is reviewed with technical details. Liver transplantation in the rat can provide important data in a variety of areas, including immunology. Nevertheless, technical problems have limited the widespread use of this valuable investigative tool. Cuff techniques for microvascular anastomosis have simplified the portal venous anastomosis and have minimized the anhepatic phase in the recipient. These had previously been the most frequent causes of failure in the utilization of liver transplantation in the rat. The technique for rat liver transplantation described here was found to be reliable with a 95.3% long-term survival (longer than 100 days) in a recent group of 85 transplants where rejection was not a factor. In the early experience, most deaths were due to bleeding, infection, and biliary complications. The improvements in technique have eliminated most of these errors. We feel that the use of these technical modifications would increase the success rate of rat liver transplantation in the hands of others.