Difference in age at regression and without Down syndrome
Difference in age at regression and without Down syndrome
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DOI：
10.1097/dbp.0b013e318165c78d
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发表时间：
2008-04-01
影响因子：
2.4
通讯作者：
Molloy, Cynthia A.
中科院分区：
文献类型：
--
作者：
Castillo, Heidi;Patterson, Bonnie;Molloy, Cynthia A.
目的：孤独症在唐氏综合征患者中的发生率高于一般人群。据报道，在患有自闭症和唐氏综合症的儿童中，退化发生率高达50%。本研究的目的是描述和比较有和没有唐氏综合征的自闭症儿童的回归。研究方法：在这项病例对照研究中，将患有唐氏综合征和以发育退化史为特征的自闭症的儿童（n = 12）与患有退化的自闭症但没有患有唐氏综合征的儿童进行比较，年龄和性别匹配。比较了年龄在收购的语言和年龄在失去语言和其他技能的自闭症诊断访谈修订版（ADI-R）。结果如下：唐氏综合征和自闭症儿童获得有意义的单个单词使用的平均年龄为40.6个月（SD = 38.0），而无唐氏综合征的自闭症儿童为14.9个月（SD = 8.5）（p.005）。患有唐氏综合征的自闭症儿童语言丧失的平均年龄为61.8个月（SD 22.9），而没有唐氏综合征的自闭症儿童为19.7个月（SD = 5.8）（p = 0.01）。其他技能丧失的平均年龄分别为46.2个月（SD = 19.1）和19.5个月（SD = 5.6）（p = 0.006）。结论：当患有自闭症和唐氏综合症的儿童出现退化时，平均来说，比没有唐氏综合症的自闭症儿童通常看到的要晚得多。
Objective: Autism occurs more frequently in individuals with Down syndrome than it does in the general population. Among children with autism and Down syndrome, regression is reported to occur in up to 50%. The aim of this study was to characterize and compare regression in children with autism with and without Down syndrome. Methods: in this case-control study, children with Down syndrome and autism characterized by a history of developmental regression (n = 12) were compared to children with autism with regression who did not have Down syndrome, matched for chronologic age and gender. Comparisons were made on age at acquisition of language and age at loss of language and other skills as measured by the Autism Diagnostic interview-Revised (ADI-R). Results: The mean age at acquisition of meaningful use of single words was 40.6 months (SD = 38.0) in children with Down syndrome and autism compared to 14.9 months (SD = 8.5) in children with autism without Down syndrome (p.005). The mean age at language loss in children with autism with Down syndrome was 61.8 months (SD 22.9) compared to 19.7 months (SD = 5.8) for those with autism without Down syndrome (p =.01). The mean age at other skill loss was 46.2 months (SD = 19.1) and 19.5 months (SD = 5.6), respectively (p =.006). Conclusions: When regression occurs in children with autism and Down syndrome it is, on average, much later than is typically seen in children with autism without Down syndrome.