Leukocytosis, hypoalbuminemia, and the risk for chronic kidney disease in US adults
Leukocytosis, hypoalbuminemia, and the risk for chronic kidney disease in US adults
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DOI：
10.1016/s0272-6386(03)00650-4
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发表时间：
2003-08-01
影响因子：
13.2
通讯作者：
Brancati, FL
中科院分区：
文献类型：
--
作者：
Erlinger, TP;Tarver-Carr, ME;Brancati, FL
背景动脉粥样硬化和慢性肾脏疾病（CKD）有几个共同的前因。然而，炎症标志物和CKD事件之间的关联尚不清楚。研究方法：我们确定了9，250名年龄在30至74岁之间的美国成年人的CKD事件风险，这些成年人参加了第二次全国健康和营养检查调查（NHANES 11），这是一项具有全国代表性的前瞻性队列研究，随访17年。结果在校正年龄、种族、性别、血压、吸烟和体重指数后，总白色细胞（WBC）计数增加与CKD风险呈分级正相关（P趋势
Background. Atherosclerosis and chronic kidney disease (CKD) share several common antecedents. However, the association between inflammatory markers and incident CKD is unknown. Methods: We determined risk for incident CKD, defined by treatment for kidney failure or death related to kidney disease, in 9,250 US adults aged 30 to 74 years who participated in the Second National Health and Nutrition Examination Survey (NHANES 11), a nationally representative prospective cohort study with 17 years of follow-up. Results After adjusting for age, race, sex, blood pressure, smoking, and body mass index, there was a graded positive association with increasing total white blood cell (WBC) count and risk for CKD (P for trend