Numerical estimation of blood damage in artificial organs
Numerical estimation of blood damage in artificial organs
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DOI：
10.1111/j.1525-1594.2004.07265.x
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发表时间：
2004-05-01
影响因子：
2.4
通讯作者：
Affeld, K
中科院分区：
文献类型：
--
作者：
Goubergrits, L;Affeld, K
本研究的目的是确定一种血液损伤数值估计方法。通常，人或动物血液用于人造器官裂解的体外评估。然而，血液也有一些缺点：较大的生物变异性和不同的初始测试条件导致测试结果不可重复。因此，采用数值方法来估计血液损伤将是一个优势。该方法基于人工器官流场中沿路径线的综合溶血和血小板溶解指数的计算。与时间相关的剪切应力相关的裂解基于已知的实验数据。为了校准这些数据，该方法首先应用于人体的血液循环。结果表明，已知数据高估了溶血大约 25 倍。接下来，该方法应用于标准 Bjork-Shiley 阀。使用计算流体动力学程序 FLUENT 模拟通过阀门的流动。裂解的计算被装入 FLUENT 中并自动完成。结果显示，Bjork-Shiley瓣膜植入人体循环后，溶血指数增加7%。
The aim of this study was to determine a method for the numerical estimation of blood damage. Normally, human or animal blood is used for in vitro evaluation of lysis by artificial organs. However, blood has some disadvantages: large biological variability and different initial test conditions lead to nonreproducible test results. For that reason, it would be an advantage to have a numerical method for blood damage estimation. This proposed method is based on the calculation of an integrated hemolysis and platelet lysis index along the path line in the flow field of the artificial organ. The time-dependent shear stress related lysis is based on known experimental data. In order to calibrate these data, the method was first applied to blood circulation in the human body. The results showed that the known data overestimate hemolysis by a factor of approximately 25. Next, the method was applied to a standard Bjork-Shiley valve. The flow through a valve was simulated with the computational fluid dynamics program FLUENT. The calculation of lysis was Lidded into FLUENT and done automatically. The results showed that the Bjork-Shiley valve increased the hemolysis index by 7% if implanted in the human body circulation.