Multiple ADH genes are associated with upper aerodigestive cancers
Multiple ADH genes are associated with upper aerodigestive cancers
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DOI：
10.1038/ng.151
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发表时间：
2008-06-01
期刊：
影响因子：
30.8
通讯作者：
Brennan, Paul
中科院分区：
文献类型：
--
作者：
Hashibe, Mia;Mckay, James D.;Brennan, Paul
酒精是上呼吸道消化道癌症的重要危险因素，主要由乙醇脱氢酶（ADH）代谢。我们在三项单独研究中研究了超过3，800例呼吸消化道癌症病例和5，200例对照中的六种ADH遗传变异。在每项单独研究和总体研究中，基因变体rs 1229984（ADH 1B）和rs 1573496（ADH 7）对呼吸消化道癌具有显着的保护作用（分别为P = 10（-10）和10（-9））。随着饮酒量的增加，这些影响变得更加明显（趋势P值分别为0.0002和0.065）。这两种基因效应是相互独立的，这意味着多个ADH基因可能参与上呼吸消化道癌的病因。
Alcohol is an important risk factor for upper aerodigestive cancers and is principally metabolized by alcohol dehydrogenase (ADH) enzymes. We have investigated six ADH genetic variants in over 3,800 aerodigestive cancer cases and 5,200 controls from three individual studies. Gene variants rs1229984 (ADH1B) and rs1573496 (ADH7) were significantly protective against aerodigestive cancer in each individual study and overall (P = 10(-10) and 10(-9), respectively). These effects became more apparent with increasing alcohol consumption (P for trend = 0.0002 and 0.065, respectively). Both gene effects were independent of each other, implying that multiple ADH genes may be involved in upper aerodigestive cancer etiology.