Anterior Lens Curvature Matters in the Course of Primary Angle Closure: An Analysis Based on Ultrasound Biomicroscopic Imaging.
Anterior Lens Curvature Matters in the Course of Primary Angle Closure: An Analysis Based on Ultrasound Biomicroscopic Imaging.
复制标题
晶状体前曲率在初级房角闭合过程中的影响：基于超声生物显微成像的分析
DOI：
10.1155/2022/5570633
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发表时间：
2022
影响因子：
1.9
通讯作者：
Chen Y
中科院分区：
文献类型：
--
作者：
Liu T;Li M;Chen X;Jiang Z;Li X;Sun X;Wang J;Chen Y
评估晶状体前表面曲率在原发性闭角型青光眼（PAC）中的作用，并寻找晶状体可能使原发性闭角型青光眼易于急性发作的其他解剖特征。
本研究纳入了435只眼（263名受试者）。根据房角结构和临床特征将眼睛分为四组：（i）急性原发性闭角型青光眼（APAC，140只眼）；（ii）慢性原发性闭角型青光眼（CPAC，116只眼）；（iii）原发性闭角型青光眼疑似患者（PACS，84只眼）；（iv）正常对照组（95只眼）。所有患者均接受了全面的眼科检查，包括压平眼压测量、房角镜检查、低相干干涉测量以及超声生物显微镜成像。根据超声生物显微镜成像测量得到的全景眼前节图像，使用最小二乘法曲线拟合技术计算晶状体前表面曲率半径（ALR）。采用混合效应线性模型进行单变量和多变量分析，比较不同组之间的ALR以及眼轴长度（AL）、前房深度（ACD）和晶状体厚度（LT）。
APAC、CPAC和PACS组的ALR均比正常对照组更陡峭，AL更短，ACD更浅，LT更厚。APAC组与CPAC组或PACS组的眼睛在ACD和LT上进一步存在差异。此外，与CPAC、PACS和正常对照组相比，APAC组的ALR也更陡峭。
更陡峭的ALR可能使PAC易于急性发作。除了晶状体的相对位置和大小外，晶状体曲率是导致原发性闭角型青光眼病理生理机制的另一个变量。
To evaluate the effect of anterior lens curvature in primary angle closure (PAC) and find additional anatomical features of crystalline lens that may predispose primary angle closure to the acute course. 435 eyes (263 subjects) were enrolled in this study. Four groups of eyes were included based on angle configurations and clinical features: (i) acute primary angle closure (APAC, 140 eyes); (ii) chronic primary angle closure (CPAC, 116 eyes); (iii) primary angle closure suspect (PACS, 84 eyes); and (iv) normal controls (95 eyes). All patients underwent thorough ophthalmic exams including applanation tonometry, gonioscopy, low-coherence interferometry, and ultrasound biomicroscopic imaging. Based on the panoramic anterior segment images from ultrasound biomicroscopic imaging measurements, the radius of anterior lens curvature (ALR) was calculated using the least-squares curve fitting technique. ALR, in addition to axial length (AL), anterior chamber depth (ACD), and lens thickness (LT), was compared among different groups using univariate and multivariate analysis with mixed effects linear model. APAC, CPAC, and PACS groups all had steeper ALR, shorter AL, shallower ACD, and thicker LT than normal control group. ACD and LT further differ between APAC and CPAC or PACS eyes. Moreover, a steeper ALR was also found in the APAC group as compared to CPAC, PACS, and normal control groups. A steeper ALR may predispose the acute attack of PAC. In addition to the relative lens position and size, lens curvature is another variable that contributes to the pathophysiological mechanisms of primary angle closure.