Calcium signalling and calcium transport in bone disease.
Calcium signalling and calcium transport in bone disease.
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DOI：
10.1007/978-1-4020-6191-2_21
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发表时间：
2007
影响因子：
--
通讯作者：
Harry C. Blair;Paul H. Schlesinger;C. L. Huang;Mone Zaidi
中科院分区：
文献类型：
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作者：
Harry C. Blair;Paul H. Schlesinger;C. L. Huang;Mone Zaidi
在许多情况下，通过对骨代谢紊乱疾病的研究发现了骨细胞中的钙转运和钙信号传导机制。钙基质沉积主要由磷酸盐生成驱动，骨沉积紊乱包括膜磷酸盐运输异常，如软骨钙化症，以及产磷酶缺陷，如低磷酸症。基质的去除是由酸化驱动的，酸化会溶解矿物。破骨细胞从骨基质中去除钙的障碍导致骨质疏松。另一方面，尽管骨是细胞外钙管理的核心，但骨不是主要的钙感知器官，尽管钙感知蛋白在成骨细胞和破骨细胞中都有表达。细胞内钙信号参与二次调控，包括细胞运动和存活，但这些发现与特定疾病的关系尚不清楚。作为信号级联反应的一部分，细胞内钙信号可能调节细胞存活与增殖或合成代谢功能反应的平衡，该信号级联反应整合了通过细胞拉伸、雌激素、酪氨酸激酶和肿瘤坏死因子受体对主要信号的反应
Calcium transport and calcium signalling mechanisms in bone cells have, in many cases, been discovered by study of diseases with disordered bone metabolism. Calcium matrix deposition is driven primarily by phosphate production, and disorders in bone deposition include abnormalities in membrane phosphate transport such as in chondrocalcinosis, and defects in phosphate-producing enzymes such as in hypophosphatasia. Matrix removal is driven by acidification, which dissolves the mineral. Disorders in calcium removal from bone matrix by osteoclasts cause osteopetrosis. On the other hand, although bone is central to management of extracellular calcium, bone is not a major calcium sensing organ, although calcium sensing proteins are expressed in both osteoblasts and osteoclasts. Intracellular calcium signals are involved in secondary control including cellular motility and survival, but the relationship of these findings to specific diseases is not clear. Intracellular calcium signals may regulate the balance of cell survival versus proliferation or anabolic functional response as part of signalling cascades that integrate the response to primary signals via cell stretch, estrogen, tyrosine kinase, and tumor necrosis factor receptors