Relationship between physical activity and circulating fibroblast growth factor 21 in middle-aged and older adults
Relationship between physical activity and circulating fibroblast growth factor 21 in middle-aged and older adults
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DOI：
10.1016/j.exger.2020.111081
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发表时间：
2020-11-01
影响因子：
3.9
通讯作者：
Maeda, Seiji
中科院分区：
文献类型：
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作者：
Matsui, Masahiro;Kosaki, Keisei;Maeda, Seiji
目的：循环中成纤维细胞生长因子21(FGF21)水平随着年龄的增长而升高，并可能通过脂糖代谢受损导致心脏代谢性疾病的发生。虽然体力活动可以降低心脏代谢功能障碍的风险，但循环FGF21水平是否受到体力活动的影响仍不清楚。为探讨中老年人日常体育活动与循环FGF21水平的关系。方法：采用双抗体夹心法测定110名中老年人和102名老年人的循环FGF21水平，并用单轴加速仪测定中老年人进行轻强度运动(LPA)和中强度运动(MVPA)的时间。结果：老年组血清FGF21水平(158pg/mL)显著高于中年组(117pg/mL)。当我们研究年龄(中年或老年)和MVPA(低于或高于中位数)组的联合相关性时，老年和MVPA升高组的血清FGF21水平(116pg/mL)显著低于老年和低MVPA组(176pg/mL)。中年组MVPA低、高两组间血清FGF21水平差异无统计学意义。在多变量线性回归分析中，在调整了老年人的潜在协变量(β=-0.209)后，血清FGF21水平是由MVPA时间独立决定的。结论：这些横断面研究结果表明，在MVPA中花费的时间是循环FGF21水平的独立决定因素，习惯性地进行MVPA可以缓解与年龄相关的血清FGF21水平的升高。(250/250字)。
Objective: Circulating levels of fibroblast growth factor 21 (FGF21) increase with advancing age and may lead to the development of cardiometabolic diseases via impaired lipid and glucose metabolism. While physical activity can reduce these risks of cardiometabolic dysfunction, it remains obscure whether circulation FGF21 levels are influenced by physical activity. The purpose of this study was to investigate the relations between daily physical activities and circulating FGF21 levels in middle-aged and older adults.Methods: In this cross-sectional study with 110 middle-aged and 102 older adults, circulating (serum) FGF21 levels were evaluated by enzyme-linked immunosorbent assay, and the time spent in light-intensity physical activity (LPA) and moderate-to-vigorous-intensity physical activity (MVPA) was assessed using a uniaxial accelerometer.Results: Serum FGF21 levels in the older group (158 pg/mL) were significantly higher than those in the middle-aged group (117 pg/mL). When we examined the joint association of age (middle-aged or older) and MVPA (lower or higher than the median) groups, serum FGF21 levels in the older and higher MVPA group (116 pg/mL) were significantly lower than those in the older and lower MVPA group (176 pg/mL). However, there was no difference in serum FGF21 levels between the lower and higher MVPA groups in the middle-aged group. In multivariable liner regression analysis, serum FGF21 levels were independently determined by MVPA time after adjusting for potential covariates in older adults (beta = -0.209).Conclusions: These cross-sectional study findings indicate that the time spent in MVPA is an independent determinant of circulating FGF21 levels, and that an age-related increase in serum FGF21 levels may be attenuated by habitually performing MVPA. (250/250 words).