Relative risk of Alzheimer disease and age-at-onset distributions, based on APOE genotypes among elderly African Americans, Caucasians, and Hispanics in New York City.
Relative risk of Alzheimer disease and age-at-onset distributions, based on APOE genotypes among elderly African Americans, Caucasians, and Hispanics in New York City.
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DOI：
10.7916/d80v9r96
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发表时间：
1996-03
影响因子：
9.8
通讯作者：
M. Tang;Gladys E. Maestre;W. Tsai;Xinhua Liu;Lin Feng;Wai-Yee Chung;M. Chun;P. Schofield;Y. Stern;B. Tycko;R. Mayeux
中科院分区：
文献类型：
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作者：
M. Tang;Gladys E. Maestre;W. Tsai;Xinhua Liu;Lin Feng;Wai-Yee Chung;M. Chun;P. Schofield;Y. Stern;B. Tycko;R. Mayeux
载脂蛋白e -epsilon 4 （APOE-epsilon 4）一直与阿尔茨海默病（AD）相关，并可能导致发病年龄提前。我们之前报道过APOE-epsilon 4与非裔美国人AD之间的关联减弱。使用一种允许包含审查信息的新方法，我们比较了APOE基因型在纽约社区三个种族群体中扩大的病例和对照中的相对风险。与APOE-epsilon 3/epsilon 3基因型相比，与APOE-epsilon 4纯合子相关的AD的相对风险在所有种族中都增加（非裔美国人的相对风险[RR]=3.0； 95%可信区间[CI]=1.5-5.9；高加索人的相对风险[RR]= 7.3, 95% CI=2.5-21.6；西班牙人的相对风险[RR]= 2.5, 95% CI=1.1-5.7）。APOE-epsilon 4杂合白种人（RR=2.9, 95% CI=1.7-5.1）和西班牙裔（RR=1.6, 95% CI=1.1-2.3）的风险也增加，但非裔美国人（RR=0.6, 95% CI= 0.4-0.9）没有增加。APOE-epsilon 4纯合子和APOE-epsilon 4杂合子个体中无AD的高加索人和西班牙人的年龄分布始终低于其他APOE基因型个体。在非裔美国人中，这种关系仅在APOE-epsilon 4纯合子中观察到。这些结果证实了APOE基因型影响白种人和西班牙裔人AD的RR。APOE-epsilon 4杂合子非洲裔美国人之间的风险差异表明，其他遗传或环境因素可能会改变APOE-epsilon 4在某些人群中的作用。
Apolipoprotein-E epsilon 4 (APOE-epsilon 4) has been consistently associated with Alzheimer disease (AD) and may be responsible for an earlier age at onset. We have previously reported a diminished association between APOE-epsilon 4 and AD in African Americans. Using a new method, which allows inclusion of censored information, we compared relative risks by APOE genotypes in an expanded collection of cases and controls from three ethnic groups in a New York community. The relative risk for AD associated with APOE-epsilon 4 homozygosity was increased in all ethnic groups (African American relative risk [RR]=3.0; 95% confidence interval [CI]=1.5-5.9; Caucasian RR=7.3, 95% CI=2.5-21.6; and Hispanic RR=2.5, 95% CI=1.1-5.7), compared with those with APOE-epsilon 3/epsilon 3 genotypes. The risk was also increased for APOE-epsilon 4 heterozygous Caucasians (RR=2.9, 95% CI=1.7-5.1) and Hispanics (RR=1.6, 95% CI=1.1-2.3), but not for African Americans (RR=0.6, 95% Ci=0.4-0.9). The age distribution of the proportion of Caucasians and Hispanics without AD was consistently lower for APOE-epsilon 4 homozygous and APOE-epsilon 4 heterozygous individuals than for those with other APOE genotypes. In African Americans this relationship was observed only in APOE-epsilon 4 homozygotes. These results confirm that APOE genotypes influence the RR of AD in Caucasians and Hispanics. Differences in risk among APOE-epsilon 4 heterozygote African Americans suggest that other genetic or environmental factors may modify the effect of APOE-epsilon 4 in some populations.