The importance of P and type 1 fimbriae for the persistence of Escherichia coli in the human gut
The importance of P and type 1 fimbriae for the persistence of Escherichia coli in the human gut
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P 菌毛和 1 型菌毛对于大肠杆菌在人类肠道中持久存在的重要性
DOI：
10.1017/s095026880004992x
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发表时间：
1992
影响因子：
4.2
通讯作者：
Roland Möllby
中科院分区：
文献类型：
--
作者：
K. Tullus;I. Kühn;I. Ørskov;F. Ørskov;Roland Möllby
对89例婴儿的粪便大肠杆菌菌群进行了研究。每个婴儿在0至18个月大期间平均随访12个粪便样本（范围5-21）。对所有分离株进行P菌毛测定和生化表型分析，并确定每种菌株（表型）在婴儿肠道中的持久性。在一部分菌株中，研究了1型菌毛的发生和对HeLa细胞的粘附。定植时间超过6个月的菌株中有31%的分离株表达了P菌毛，而定植1 - 6个月或定植时间不到1个月的菌株中有19%的分离株表达了P菌毛。在所有菌株组中，1型菌毛和对HeLa细胞的粘附情况相似。我们的结论是，P型菌毛，而不是1型菌毛或HeLa细胞粘附似乎有助于大肠杆菌菌株在人肠道内定植的能力。
SUMMARY The faecal Escherichia coli flora was studied in 89 infants. Each infant was followed with a mean of 12 faecal samples (range 5–21) between 0 and 18 months of age. All isolates were assayed for P fimbriae and biochemically phenotyped and the persistence of each strain (phenotype) in the infant's gut was determined. In a subset of strains the occurrence of type 1 fimbriae and adherence to HeLa cells was studied. Thirty-one per cent of isolates belonging to strains colonizing for longer than 6 months expressed P fimbriae compared to 19% of the isolates from strains colonizing 1–6 months or transient strains colonizing less than 1 month. Type 1 fimbriae and adherence to HeLa cells occurred similarly often in all groups of strains. We conclude that P fimbriae, but not type 1 fimbriae or HeLa cell adherence seemed to contribute to the ability of the E. coli strain to colonize the human intestine.