REGIONAL SPECIFICITY IN THE EFFECT OF ESTROGEN IMPLANTATION WITHIN THE FOREBRAIN ON THE FREQUENCY OF PULSATILE LUTEINIZING-HORMONE SECRETION IN THE OVARIECTOMIZED RAT
REGIONAL SPECIFICITY IN THE EFFECT OF ESTROGEN IMPLANTATION WITHIN THE FOREBRAIN ON THE FREQUENCY OF PULSATILE LUTEINIZING-HORMONE SECRETION IN THE OVARIECTOMIZED RAT
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DOI：
10.1159/000124032
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发表时间：
1984-01-01
影响因子：
4.1
通讯作者：
KIMURA, F
中科院分区：
文献类型：
--
作者：
AKEMA, T;TADOKORO, Y;KIMURA, F
在卵巢切除大鼠前脑内不同区域局部植入晶体苯甲酸雌二醇（EB）前后，评价了促黄体生成素（LH）的脉冲式分泌。通过留置心导管以6分钟间隔采集样本，用放射免疫法测定血清LH浓度。在视交叉上区（POSC）、斜角束核和Broca斜角带（DBB）植入EB的大鼠中，LH平均浓度和LH脉冲频率迅速下降，而脉冲幅度在植入后3 h内没有变化。将EB植入终纹床核、内侧视前区、内侧隔核、下丘脑前区或第三脑室的大鼠LH分泌脉冲频率无变化。孕酮植入卵巢切除大鼠的POSC LH分泌谱没有显着变化。雌激素降低LH脉冲频率的作用部位显然不是肾上腺，而是局限于卵巢切除大鼠大脑的一小部分，包括POSC和DBB。
Pulsatile secretion of luteinizing hormone (LH) in ovariectomized rats was evaluated before and after local implantation of crystalline estradiol benzoate (EB) into various regions within the forebrain. Serum concentrations of LH were measured by radioimmunoassay in samples collected at 6-min intervals through indwelling cardiac catheters. In rats with EB implanted in the preoptic suprachiasmatic area (POSC), and in the nucleus of the tractus diagonalis and the diagonal band of Broca (DBB) to a lesser extent, the mean LH concentration and LH pulse frequency decreased rapidly while the pulse amplitude did not change for 3 h after implantation. Rats with the EB implant in the bed nucleus of stria terminals, the medial preoptic area, the medial septal nucleus, the anterior hypothalamic area or the 3rd ventricle showed unchanged frequencies of LH secretory pulses. Implantation of progesterone into the POSC of ovariectomized rats produced no significant change in LH secretory profiles. The sites of action of estrogen in decreasing the LH pulse frequency apparently are not widespeard but rather restricted within a small part of the brain including the POSC, and DBB, in the ovariectomized rat.